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Rhamnogalacturonan-...
Rhamnogalacturonan-I based microcapsules for targeted drug release
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Svagan, A. J. (author)
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Kusic, A. (author)
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De Gobba, C. (author)
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Larsen, F. H. (author)
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Sassene, P. (author)
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- Zhou, Qi (author)
- KTH,Glykovetenskap
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Van De Weert, M. (author)
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Mullertz, A. (author)
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Jørgensen, B. (author)
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Ulvskov, P. (author)
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(creator_code:org_t)
- 2016-12-19
- 2016
- English.
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In: PLOS ONE. - : Public Library of Science. - 1932-6203. ; 11:12
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Drug targeting to the colon via the oral administration route for local treatment of e.g. inflammatory bowel disease and colonic cancer has several advantages such as needle-free administration and low infection risk. A new source for delivery is plant-polysaccharide based delivery platforms such as Rhamnogalacturonan-I (RG-I). In the gastro-intestinal tract the RG-I is only degraded by the action of the colonic microflora. For assessment of potential drug delivery properties, RG-I based microcapsules (~1 μm in diameter) were prepared by an interfacial poly-addition reaction. The cross-linked capsules were loaded with a fluorescent dye (model drug). The capsules showed negligible and very little in vitro release when subjected to media simulating gastric and intestinal fluids, respectively. However, upon exposure to a cocktail of commercial RG-I cleaving enzymes, ~ 9 times higher release was observed, demonstrating that the capsules can be opened by enzymatic degradation. The combined results suggest a potential platform for targeted drug delivery in the terminal gastro-intestinal tract.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Svagan, A. J.
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Kusic, A.
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De Gobba, C.
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Larsen, F. H.
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Sassene, P.
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Zhou, Qi
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show more...
-
Van De Weert, M.
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Mullertz, A.
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Jørgensen, B.
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Ulvskov, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Pharmaceutical S ...
- Articles in the publication
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PLOS ONE
- By the university
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Royal Institute of Technology