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Molecular interroga...
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes
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Romanov, Roman A. (author)
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- Zeisel, Amit (author)
- Karolinska Institutet
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- Bakker, Joanne (author)
- Karolinska Institutet
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Girach, Fatima (author)
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Hellysaz, Arash (author)
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Tomer, Raju (author)
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Alpar, Alan (author)
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- Mulder, Jan (author)
- Karolinska Institutet
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Clotman, Frederic (author)
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Keimpema, Erik (author)
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Hsueh, Brian (author)
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Crow, Ailey K. (author)
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Martens, Henrik (author)
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Schwindling, Christian (author)
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- Calvigioni, Daniela (author)
- Karolinska Institutet
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Bains, Jaideep S. (author)
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Mate, Zoltan (author)
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Szabo, Gabor (author)
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Yanagawa, Yuchio (author)
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- Zhang, Ming-Dong (author)
- Karolinska Institutet
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Rendeiro, Andre (author)
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Farlik, Matthias (author)
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi
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Wulff, Peer (author)
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Bock, Christoph (author)
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Broberger, Christian (author)
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Deisseroth, Karl (author)
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- Hokfelt, Tomas (author)
- Karolinska Institutet
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- Linnarsson, Sten (author)
- Karolinska Institutet
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Horvath, Tamas L. (author)
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- Harkany, Tibor (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2016-12-19
- 2017
- English.
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In: Nature Neuroscience. - : Nature Publishing Group. - 1097-6256 .- 1546-1726. ; 20:2, s. 176-188
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- The hypothalamus contains the highest diversity of neurons in the brain. Many of these neurons can co-release neurotransmitters and neuropeptides in a use-dependent manner. Investigators have hitherto relied on candidate protein-based tools to correlate behavioral, endocrine and gender traits with hypothalamic neuron identity. Here we map neuronal identities in the hypothalamus by single-cell RNA sequencing. We distinguished 62 neuronal subtypes producing glutamatergic, dopaminergic or GABAergic markers for synaptic neurotransmission and harboring the ability to engage in task-dependent neurotransmitter switching. We identified dopamine neurons that uniquely coexpress the Onecut3 and Nmur2 genes, and placed these in the periventricular nucleus with many synaptic afferents arising from neuromedin S+ neurons of the suprachiasmatic nucleus. These neuroendocrine dopamine cells may contribute to the dopaminergic inhibition of prolactin secretion diurnally, as their neuromedin S+ inputs originate from neurons expressing Per2 and Per3 and their tyrosine hydroxylase phosphorylation is regulated in a circadian fashion. Overall, our catalog of neuronal subclasses provides new understanding of. hypothalamic organization and function.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Romanov, Roman A ...
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Zeisel, Amit
-
Bakker, Joanne
-
Girach, Fatima
-
Hellysaz, Arash
-
Tomer, Raju
-
show more...
-
Alpar, Alan
-
Mulder, Jan
-
Clotman, Frederi ...
-
Keimpema, Erik
-
Hsueh, Brian
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Crow, Ailey K.
-
Martens, Henrik
-
Schwindling, Chr ...
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Calvigioni, Dani ...
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Bains, Jaideep S ...
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Mate, Zoltan
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Szabo, Gabor
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Yanagawa, Yuchio
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Zhang, Ming-Dong
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Rendeiro, Andre
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Farlik, Matthias
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Uhlén, Mathias
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Wulff, Peer
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Bock, Christoph
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Broberger, Chris ...
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Deisseroth, Karl
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Hokfelt, Tomas
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Linnarsson, Sten
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Horvath, Tamas L ...
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Harkany, Tibor
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
- Articles in the publication
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Nature Neuroscie ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet