Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy

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Neimert-Andersson, T.Karolinska Institutet (author)

Carbohydrate-based particles reduce allergic inflammation in a mouse model for cat allergy

Article/chapterEnglish2008

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John Wiley & Sons,2008
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LIBRIS-ID:oai:DiVA.org:kth-205254
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-205254URI
https://doi.org/10.1111/j.1398-9995.2008.01644.xDOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:116813163URI

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Language:English
Summary in:English

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QC 20170419
Background: Allergen-specific immunotherapy (ASIT) is the only treatment of allergic disease that gives long-lasting relief of symptoms. However, concerns for safety and efficiency have highlighted the need for improvement of the therapy. We have previously suggested carbohydrate-based particles (CBPs) as a novel adjuvant and allergen carrier for ASIT. Our aim of this study was to evaluate the therapeutic potential of CBPs in ASIT, employing a mouse model for cat allergy. Methods: BALB/c mice were subcutaneously immunized with the recombinant (r) cat allergen Fel d 1 followed by intranasal challenge with cat dander extract (CDE). The sensitized mice were therapeutically treated with rFel d 1 covalently coupled to CBPs (CBP-rFel d 1). Airway hyper-reactivity (AHR), infiltration of leucocytes in bronchoalveolar lavage (BAL) fluid, allergen-specific serum immunoglobulin levels and in vitro splenocyte responses were evaluated. Results: Mice treated with CBP-rFel d 1 showed reduced features of allergic inflammation. They responded with (i) significantly decreased AHR and infiltration of eosinophils in BAL fluid after CDE challenge, (ii) the serum level of rFel d 1-specific IgE was reduced and the level of IgG(2)a was more pronounced after CBP-rFel d 1 treatment, and (iii) there was also a tendency of decreased allergen-specific cellular response. Conclusions: Carbohydrate-based particles are effective tools as adjuvant and allergen carriers for use in ASIT and constitutes a promising strategy to improve allergy treatment.

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Thunberg, Sarah,1976-Karolinska Institutet(Swepub:kth)u1rw1xrj (author)
Swedin, L.Karolinska Institutet, Sweden (author)
Wiedermann, U.Medical University Vienna, Austria (author)
Jacobsson-Ekman, G.Karolinska Institutet (author)
Dahlen, S. -EKarolinska Institutet (author)
Scheynius, A.Karolinska Institutet (author)
Gronlund, H.Karolinska Institutet (author)
van Hage, M.Karolinska Institutet (author)
Gafvelin, G.Karolinska Institutet, Sweden (author)
Karolinska InstitutetKarolinska Institutet, Sweden (creator_code:org_t)

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In:Allergy. European Journal of Allergy and Clinical Immunology: John Wiley & Sons63:5, s. 518-5260105-45381398-9995

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine

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