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Characterization and MRI study of surfactant-coated superparamagnetic nanoparticles administered into the rat brain
- Kim, D. K. (author)
- Zhang, Y. (author)
-
- Kehr, J. (author)
- Karolinska Institutet
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- Klason, T. (author)
- Bjelke, B. (author)
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- (creator_code:org_t)
- 2001
- 2001
- English.
- In: Journal of Magnetism and Magnetic Materials. - 0304-8853 .- 1873-4766. ; 225:02-jan, s. 256-261
- Journal article (peer-reviewed)
Abstract
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- A pre-clinical study has been carried out for the utilization of magnetite (Fe-3 O-4) nanoparticles as a diagnostic tracer for MRI. Surfactant-coated Fe3O4 nanoparticles have been synthesized by a chemical coprecipitation method with a narrow particle size of around 6 nm. Preliminary experiments demonstrated the feasibility of using superparamagnetic Fe-3 O-4 nanoparticles as contrast agents in MR imaging.
Keyword
- nanoparticles
- superparamagnetism
- MRI
- iron oxide
- brain
- rat
- contrast agent
- gene-expression
- kinetics
- galanin
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- ref (subject category)
- art (subject category)
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- Kim, D. K.
- Zhang, Y.
- Kehr, J.
- Klason, T.
- Bjelke, B.
- Muhammed, Mamoun
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- Royal Institute of Technology
- Karolinska Institutet
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