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Oriented clonal cel...
Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
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- Kaucka, Marketa (author)
- Karolinska Institutet
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Zikmund, Tomas (author)
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Tesarova, Marketa (author)
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- Gyllborg, Daniel (author)
- Karolinska Institutet
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- Hellander, Andreas (author)
- Uppsala universitet,Avdelningen för beräkningsvetenskap,Tillämpad beräkningsvetenskap
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- Jaros, Josef (author)
- Karolinska Institutet
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Kaiser, Jozef (author)
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Petersen, Julian (author)
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Szarowska, Bara (author)
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- Newton, Phillip T. (author)
- Karolinska Institutet
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- Dyachuk, Vyacheslav (author)
- Karolinska Institutet
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li, Lei (author)
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- Qian, Hong (author)
- Karolinska Institutet
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Johansson, Anne-Sofie (author)
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Mishina, Yuji (author)
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Currie, Joshua D. (author)
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Tanaka, Elly M. (author)
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Erickson, Alek (author)
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Dudley, Andrew (author)
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- Brismar, Hjalmar (author)
- Karolinska Institutet,KTH,Cellulär biofysik,Science for Life Laboratory, SciLifeLab
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Southam, Paul (author)
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Coen, Enrico (author)
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Chen, Min (author)
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Weinstein, Lee S. (author)
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Hampl, Ales (author)
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- Arenas, Ernest (author)
- Karolinska Institutet
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- Chagin, Andrei S. (author)
- Karolinska Institutet
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- Fried, Kaj (author)
- Karolinska Institutet
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- Adameyko, Igor (author)
- Karolinska Institutet
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Currie, Josh (author)
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(creator_code:org_t)
- Elife Sciences Publications LTD, 2017
- 2017
- English.
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In: eLIFE. - : Elife Sciences Publications LTD. - 2050-084X. ; 6
- Related links:
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https://doi.org/10.7...
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https://urn.kb.se/re...
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https://doi.org/10.7...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik -- Biomaterial (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology -- Bio Materials (hsv//eng)
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
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eLIFE
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
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Kaucka, Marketa
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Zikmund, Tomas
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Tesarova, Market ...
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Gyllborg, Daniel
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Hellander, Andre ...
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Jaros, Josef
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show more...
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Kaiser, Jozef
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Petersen, Julian
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Szarowska, Bara
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Newton, Phillip ...
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Dyachuk, Vyaches ...
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li, Lei
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Qian, Hong
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Johansson, Anne- ...
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Mishina, Yuji
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Currie, Joshua D ...
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Tanaka, Elly M.
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Erickson, Alek
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Dudley, Andrew
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Brismar, Hjalmar
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Southam, Paul
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Coen, Enrico
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Chen, Min
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Weinstein, Lee S ...
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Hampl, Ales
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Arenas, Ernest
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Chagin, Andrei S ...
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Fried, Kaj
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Adameyko, Igor
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Currie, Josh
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show less...
- About the subject
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Industrial Biote ...
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and Bio Materials
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Cell Biology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Computer and Inf ...
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and Bioinformatics
- Articles in the publication
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eLIFE
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University