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Systemic Hypoxia In...
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Chowdhury, Helena H
(author)
Systemic Hypoxia Increases the Expression of DPP4 in Preadipocytes of Healthy Human Participants
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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2017-09-26
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Georg Thieme Verlag KG,2017
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-216424
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-216424URI
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https://doi.org/10.1055/s-0043-113451DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20171024
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Dipeptidyl peptidase 4 (DPP4) is a transmembrane glycoprotein involved in protein degradation. Due to its action on incretins, which increase insulin secretion, DPP4 is considered a therapeutic target for type 2 diabetes. Here we have studied the role of single and combined effects of hypoxia and inactivity on the expression of DPP4 in human adipose tissue of 12 adult normal-weight males. Fat biopsies were obtained at baseline and after each of three experimental campaigns. The results revealed that in isolated human preadipocytes the expression of DPP4 was significantly increased by exposure of participants to hypoxia. Physical inactivity per se had no apparent effect on the DPP4 expression. It is concluded that DPP4 may be a marker to monitor indirectly tissue hypoxia, as occurs in obese subjects.
Added entries (persons, corporate bodies, meetings, titles ...)
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Velebit, Jelena
(author)
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Mekjavic, Igor B
(author)
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Eiken, OlaKTH,Omgivningsfysiologi,Centrum för flyg- och rymdfysiologi, SAPC(Swepub:kth)u1fcwvxl
(author)
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Kreft, Marko
(author)
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Zorec, Robert
(author)
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KTHOmgivningsfysiologi
(creator_code:org_t)
Related titles
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In:Experimental and clinical endocrinology & diabetes: Georg Thieme Verlag KG0947-73491439-3646
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