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Safe therapeutics o...
Safe therapeutics of murine melanoma model using a novel antineoplasic, the partially methylated mannogalactan from Pleurotus eryngii
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Biscaia, S. M. P. (author)
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Carbonero, E. R. (author)
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Bellan, D. L. (author)
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Borges, B. S. (author)
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Costa, C. R. (author)
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Rossi, G. R. (author)
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Goncalves, J. P. (author)
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Melo, C. M. (author)
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Livero, F. A. R. (author)
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- Ruthes, Andrea C. (author)
- KTH,Glykovetenskap
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Zotz, R. (author)
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Silva, E. V. (author)
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Oliveira, C. C. (author)
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Acco, A. (author)
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Nader, H. B. (author)
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Chammas, R. (author)
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Iacomini, M. (author)
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Franco, C. R. C. (author)
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Trindade, E. S. (author)
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(creator_code:org_t)
- ELSEVIER SCI LTD, 2017
- 2017
- English.
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In: Carbohydrate Polymers. - : ELSEVIER SCI LTD. - 0144-8617 .- 1879-1344. ; 178, s. 95-104
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- A heteropolysaccharide was isolated by cold aqueous extraction from edible mushroom Pleurotus eryngii ("King Oyster") basidiocarps and its biological properties were evaluated. Structural assignments were carried out using mono-and bidimensional NMR spectroscopy, monosaccharide composition, and methylation analyses. A man-nogalactan having a main chain of (1 -> 6)-linked alpha-D-galactopyranosyl and 3-O-methyl-alpha-D-galactopyranosyl residues, both partially substituted at OH-2 by beta-D-Manp (MG-Pe) single-unit was found. Biological effects of mannogalactan from P. eryngii (MG-Pe) were tested against murine melanoma cells. MG-Pe was non-cytotoxic, but reduced in vitro melanoma cells invasion. Also, 50 mg/kg MG-Pe administration to melanoma-bearing C57BL/6 mice up to 10 days decreased in 60% the tumor volume compared to control. Additionally, no changes were observed when biochemical profile, complete blood cells count (CBC), organs, and body weight were analyzed. Mg-Pe was shown to be a promising anti-melanoma molecule capable of switching melanoma cells to a non-invasive phenotype with no toxicity to melanoma-bearing mice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Pleurotus eryngii ("King Oyster")
- Mannogalactan
- Chemical structure
- Antitumor
- Melanoma B16-F10
- Non-cytotoxic
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Biscaia, S. M. P ...
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Carbonero, E. R.
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Bellan, D. L.
-
Borges, B. S.
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Costa, C. R.
-
Rossi, G. R.
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show more...
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Goncalves, J. P.
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Melo, C. M.
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Livero, F. A. R.
-
Ruthes, Andrea C ...
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Zotz, R.
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Silva, E. V.
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Oliveira, C. C.
-
Acco, A.
-
Nader, H. B.
-
Chammas, R.
-
Iacomini, M.
-
Franco, C. R. C.
-
Trindade, E. S.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Carbohydrate Pol ...
- By the university
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Royal Institute of Technology