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Correlations in Sca...
Correlations in Scattered X-Ray Laser Pulses Reveal Nanoscale Structural Features of Viruses
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Kurta, Ruslan P. (author)
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Donatelli, Jeffrey J. (author)
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Yoon, Chun Hong (author)
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Berntsen, Peter (author)
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- Bielecki, Johan (author)
- Uppsala universitet,Molekylär biofysik
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- Daurer, Benedikt J. (author)
- Uppsala universitet,Molekylär biofysik
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DeMirci, Hasan (author)
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Fromme, Petra (author)
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- Hantke, Max Felix (author)
- Uppsala universitet,Molekylär biofysik
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- Maia, Filipe R. N. C. (author)
- Uppsala universitet,Molekylär biofysik,Science for Life Laboratory, SciLifeLab
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- Munke, Anna (author)
- Uppsala universitet,Molekylär biofysik
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Nettelblad, Carl (author)
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Pande, Kanupriya (author)
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- Reddy, Hemanth K. N. (author)
- Uppsala universitet,Molekylär biofysik
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- Sellberg, Jonas A. (author)
- Uppsala universitet,KTH,Biomedicinsk fysik och röntgenfysik,Molekylär biofysik
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Sierra, Raymond G. (author)
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- Svenda, Martin (author)
- Uppsala universitet,Molekylär biofysik
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- van der Schot, Gijs (author)
- Uppsala universitet,Molekylär biofysik
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Vartanyants, Ivan A. (author)
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Williams, Garth J. (author)
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Xavier, P. Lourdu (author)
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Aquila, Andrew (author)
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Zwart, Peter H. (author)
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Mancuso, Adrian P. (author)
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(creator_code:org_t)
- American Physical Society, 2017
- 2017
- English.
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In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 119:15
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- We use extremely bright and ultrashort pulses from an x-ray free-electron laser (XFEL) to measure correlations in x rays scattered from individual bioparticles. This allows us to go beyond the traditional crystallography and single-particle imaging approaches for structure investigations. We employ angular correlations to recover the three-dimensional (3D) structure of nanoscale viruses from x-ray diffraction data measured at the Linac Coherent Light Source. Correlations provide us with a comprehensive structural fingerprint of a 3D virus, which we use both for model-based and ab initio structure recovery. The analyses reveal a clear indication that the structure of the viruses deviates from the expected perfect icosahedral symmetry. Our results anticipate exciting opportunities for XFEL studies of the structure and dynamics of nanoscale objects by means of angular correlations.
Subject headings
- NATURVETENSKAP -- Fysik -- Atom- och molekylfysik och optik (hsv//swe)
- NATURAL SCIENCES -- Physical Sciences -- Atom and Molecular Physics and Optics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
Keyword
- Free-Electron Laser
- Diffraction Data
- Angular-Correlations
- Atomic-Structure
- Image-Formation
- Symmetries
- Particles
- Protein
- Classification
- Reconstruction
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Kurta, Ruslan P.
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Donatelli, Jeffr ...
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Yoon, Chun Hong
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Berntsen, Peter
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Bielecki, Johan
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Daurer, Benedikt ...
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show more...
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DeMirci, Hasan
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Fromme, Petra
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Hantke, Max Feli ...
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Maia, Filipe R. ...
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Munke, Anna
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Nettelblad, Carl
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Pande, Kanupriya
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Reddy, Hemanth K ...
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Sellberg, Jonas ...
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Sierra, Raymond ...
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Svenda, Martin
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van der Schot, G ...
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Vartanyants, Iva ...
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Williams, Garth ...
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Xavier, P. Lourd ...
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Aquila, Andrew
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Zwart, Peter H.
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Mancuso, Adrian ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Physical Science ...
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and Atom and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biophysics
- Articles in the publication
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Physical Review ...
- By the university
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Royal Institute of Technology
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Uppsala University