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Synthesis and in vi...
Synthesis and in vitro degradation of poly(N-vinyl-2-pyrrolidone)-based graft copolymers for biomedical applications
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Brunius, C. F. (author)
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- Edlund, Ulrica (author)
- KTH,Polymerteknologi
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- Albertsson, Ann-Christine (author)
- KTH,Polymerteknologi
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(creator_code:org_t)
- 2002-09-19
- 2002
- English.
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In: Journal of Polymer Science Part A. - : Wiley. - 0887-624X .- 1099-0518. ; 40:21, s. 3652-3661
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- This work is devoted to the design of a novel family of hydrosoluble biomaterials: poly(N-vinyl-2-pyrrolidone) (PVP)-based graft copolymers. A synthesis route has been elaborated in which omega-functionalized PVP is prepared via chain-transfer radical polymerization, end-group modified, and subsequently grafted onto a polyhydroxylated backbone, typically dextran or poly(vinyl alcohol). The resulting graft copolymer biomaterials are designed for use in various biomedical applications, particularly as materials with a stronger potential for plasma expansion than already existing products have. The graft copolymers are potentially degradable because the PVP grafts are connected to the polyol backbone via a hydrolytically labile carbonate or ester linkage. The degradation of the graft copolymers was performed in vitro over a period of 6 weeks.
Keyword
- poly(vinyl pyrrolidone) (PVP)
- biomaterial
- graft copolymer
- dextran
- degradation
- expanders
- oligomers
- nmr
Publication and Content Type
- ref (subject category)
- art (subject category)
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