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  • Lomnytska, MartaUppsala universitet,Reproduktiv hälsa,Karolinska Inst, Inst Womens & Childrens Hlth, SE-17176 Stockholm, Sweden.;Karolinska Inst, Canc Ctr Karolinska, Dept Oncol & Pathol, SE-17176 Stockholm, Sweden. (author)

Platelet protein biomarker panel for ovarian cancer diagnosis

  • Article/chapterEnglish2018

Publisher, publication year, extent ...

  • 2018-01-12
  • BIOMED CENTRAL LTD,2018
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-221935
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-221935URI
  • https://doi.org/10.1186/s40364-018-0118-yDOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:142416676URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-341570URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20180131
  • Background: Platelets support cancer growth and spread making platelet proteins candidates in the search for biomarkers. Methods: Two-dimensional (2D) gel electrophoresis, Partial Least Squares Discriminant Analysis (PLS-DA), Western blot, DigiWest. Results: PLS-DA of platelet protein expression in 2D gels suggested differences between the International Federation of Gynaecology and Obstetrics (FIGO) stages III-IV of ovarian cancer, compared to benign adnexal lesions with a sensitivity of 96% and a specificity of 88%. A PLS-DA-based model correctly predicted 7 out of 8 cases of FIGO stages I-II of ovarian cancer after verification by western blot. Receiver-operator curve (ROC) analysis indicated a sensitivity of 83% and specificity of 76% at cut-off >0.5 (area under the curve (AUC) = 0.831, p < 0.0001) for detecting these cases. Validation on an independent set of samples by DigiWest with PLS-DA differentiated benign adnexal lesions and ovarian cancer, FIGO stages III-IV, with a sensitivity of 70% and a specificity of 83%. Conclusion: We identified a group of platelet protein biomarker candidates that can quantify the differential expression between ovarian cancer cases as compared to benign adnexal lesions.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Pinto, RuiImperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, St Marys Campus,Norfolk Pl, London W2 1PG, England. (author)
  • Becker, SusanneKarolinska Inst, Canc Ctr Karolinska, Dept Oncol & Pathol, SE-17176 Stockholm, Sweden. (author)
  • Engstrom, UllaLudwig Inst Canc Res Ltd, Box 595, SE-75124 Uppsala, Sweden. (author)
  • Gustafsson, SonjaNeoProteomics AB, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden. (author)
  • Bjorklund, ChristinaNeoProteomics AB, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden. (author)
  • Templin, MarkusUniv Tubingen, NMI Nat & Med Sci Inst, D-72770 Reutlingen, Germany. (author)
  • Bergstrand, JanKTH,Experimentell biomolekylär fysik,AlbaNova Univ Ctr, Royal Inst Technol, Dept Appl Phys, Expt Biomol Phys, SE-10691 Stockholm, Sweden.(Swepub:kth)u1xi97g1 (author)
  • Xu, LeiKTH,Experimentell biomolekylär fysik,AlbaNova Univ Ctr, Royal Inst Technol, Dept Appl Phys, Expt Biomol Phys, SE-10691 Stockholm, Sweden.(Swepub:kth)u1zr7k1u (author)
  • Widengren, JerkerKTH,Experimentell biomolekylär fysik,AlbaNova Univ Ctr, Royal Inst Technol, Dept Appl Phys, Expt Biomol Phys, SE-10691 Stockholm, Sweden.(Swepub:kth)u1i3g09c (author)
  • Epstein, ElisabethKarolinska Institutet,Karolinska Inst, Inst Womens & Childrens Hlth, SE-17176 Stockholm, Sweden.;Soder Sjukhuset, Dept Clin Sci & Educ, Dept Obstet & Gynaecol, SE-11883 Stockholm, Sweden. (author)
  • Franzen, BoKarolinska Institutet,Karolinska Inst, Canc Ctr Karolinska, Dept Oncol & Pathol, SE-17176 Stockholm, Sweden.;NeoProteomics AB, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden. (author)
  • Auer, GertKarolinska Institutet,Karolinska Inst, Canc Ctr Karolinska, Dept Oncol & Pathol, SE-17176 Stockholm, Sweden.;NeoProteomics AB, Canc Ctr Karolinska, SE-17176 Stockholm, Sweden. (author)
  • Uppsala universitetReproduktiv hälsa (creator_code:org_t)

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  • In:Biomarker Research: BIOMED CENTRAL LTD62050-7771

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