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- Alander, E. M. (author)
Characterization of paracetamol agglomerates by image analysis and strength measurement
- Article/chapterEnglish2003
Publisher, publication year, extent ...
- Elsevier BV,2003
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-22348
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-22348URI
- https://doi.org/10.1016/S0032-5910(02)00208-5DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- QC 20100525
- Paracetamol is crystallized in different solvents and techniques are developed and used to characterize the product. The product particles from three different solvent compositions: ethylene glycol, acetone and an acetone-water mixture (30-70 wt.%) have been examined. Product properties visually observed are quantified by image analysis and evaluation of measured image descriptors with Principal Component Analysis (PCA). The agglomerate strength has been determined by crushing single agglomerates. Depending on the solvent, the content of single crystals and agglomerates differ. Agglomerates differ by the number and size of crystals grown together, as well as by the strength.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Farmaceutiska vetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences hsv//eng
- crystallization
- agglomeration
- image analysis
- PCA
- crushing strength
- particle morphology
- quantification
- solubility
- mixtures
- crystals
- binary
- shape
Added entries (persons, corporate bodies, meetings, titles ...)
- Uusi-Penttila, M. S. (author)
- Rasmuson, Åke C.KTH,Kemiteknik(Swepub:kth)u1w1ulhl (author)
- KTHKemiteknik (creator_code:org_t)
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- In:Powder Technology: Elsevier BV130:1-3, s. 298-3060032-59101873-328X
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