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Lack of association...
Lack of association of CCR2-64I and CCR5-Delta 32 with type 1 diabetes and latent autoimmune diabetes in adults
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Gambelunghe, G. (author)
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- Ghaderi, M. (author)
- Karolinska Institutet
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Brozzetti, A. (author)
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Del Sindaco, P. (author)
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Gharizadeh, B. (author)
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- Nyrén, Pål (author)
- KTH,Biokemi och biokemisk teknologi
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- Hjelmstrom, P. (author)
- Karolinska Institutet
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Nikitina-Zake, L. (author)
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- Sanjeevi, C. B. (author)
- Karolinska Institutet
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Falorni, A. (author)
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Umbria Type 1 Diabetes, Registry (author)
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(creator_code:org_t)
- 2003
- 2003
- English.
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In: Human Immunology. - 0198-8859 .- 1879-1166. ; 64:6, s. 629-632
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- It is well known that type I diabetes mellitus (T1DM) is a complex genetic disease resulting from the autoimmune destruction of pancreatic beta cells. Several genes have been associated with susceptibility and/or protection for T1DM, but the disease risk is mostly influenced by genes located in the class II region of the major histocompatibility complex. The attraction of leukocytes to tissues is essential for inflammation and the beginning of autoimmune reaction. The process is controlled by chemokines, which are chemotactic cytolines. Some studies have shown that CCR2-64I and CCR5-Delta32 might be important for protection of susceptibility to some immunologically-mediated disorders. In the present study, we demonstrate the lack of association between CCR2-64I and CCR5-Delta32 gene polymorphism and TIDM and we desrcibe a new method for a simple and more precise genotyping of the CCR2 gene.
Keyword
- chemokine
- CCR2-641 gene
- CCR5-Delta 32 gene
- type 1 diabetes
- latent autoimmune diabetes of the adult
- disease progression
- gene polymorphism
- ccr5
- mellitus
- onset
- hla
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Gambelunghe, G.
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Ghaderi, M.
-
Brozzetti, A.
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Del Sindaco, P.
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Gharizadeh, B.
-
Nyrén, Pål
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show more...
-
Hjelmstrom, P.
-
Nikitina-Zake, L ...
-
Sanjeevi, C. B.
-
Falorni, A.
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Umbria Type 1 Di ...
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show less...
- Articles in the publication
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Human Immunology
- By the university
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Royal Institute of Technology
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Karolinska Institutet