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Burst dynamics under mixed NMDA and AMPA drive in the models of the lamprey spinal CPG
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- Kozlov, Alexander (author)
- KTH,Numerisk analys och datalogi, NADA,Lansner
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- Lansner, Anders (author)
- KTH,Numerisk analys och datalogi, NADA
- Grillner, S. (author)
- (creator_code:org_t)
- Elsevier BV, 2003
- 2003
- English.
- In: Neurocomputing. - : Elsevier BV. - 0925-2312 .- 1872-8286. ; 52-54, s. 65-71
- Journal article (peer-reviewed)
Abstract
Subject headings
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- The spinal CPG of the lamprey is modeled using a chain of nonlinear oscillators. Each oscillator represents a small neuron population capable of bursting under mixed NMDA and AMPA drive. Parameters of the oscillator are derived from detailed conductance-based neuron models. Analysis and simulations of dynamics of a single oscillator, a chain of locally coupled excitatory oscillators and a chain of two pairs of excitatory and inhibitory oscillators in each segment are done. The roles of asymmetric couplings and additional rostral drive for generation of a traveling wave with one cycle per chain length in a realistic frequency range are studied.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap -- Bioinformatik (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences -- Bioinformatics (hsv//eng)
Keyword
- locomotiom
- spinal cord
- lamprey
- modeling
- intersegmental phase-lag
- computer-simulations
- neural networks
- modulation
- neurons
Publication and Content Type
- ref (subject category)
- art (subject category)
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