Improved procedure for cyclization of vinyl azides into 3-substituted-2H-azirines

• A significantly improved procedure for the preparation of 3-substituted 2H-azirines has been developed. By cyclization of the corresponding vinyl azides in low boiling solvents in closed vessels at elevated temperature, high purity, short reaction time and simple isolation of the product were achieved.

Nyckelord

vinyl azide

thermolysis

azirine

diels-alder reactions

unsaturated azides

general synthesis

2h-azirines

2h-azirine-3-carboxylate

cycloadditions

dienophiles

pyrimidine

azirines

olefins

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)