Changes in brain architecture are consistent with altered fear processing in domestic rabbits

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Changes in brain architecture are consistent with altered fear processing in domestic rabbits

Brusini, Irene (author): KTH,Medicinsk avbildning,KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden

Carneiro, Miguel (author): Univ Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.;Univ Porto, Dept Biol, Fac Ciencias, P-4169007 Porto, Portugal.

Wang, Chunliang, 1980- (author): KTH,Medicinsk avbildning,KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden

Rubin, Carl-Johan (author): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab

Ring, Henrik, 1981- (author): Uppsala universitet,Medicinsk utvecklingsbiologi

Afonso, Sandra (author): Univ Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.

Blanco-Aguiar, Jose A. (author): Univ Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.;CSIC, Inst Invest Recursos Cineget IREC, Ciudad Real 13005, Spain.;UCLM, CSIC, Ciudad Real 13005, Spain.

Ferrand, Nuno (author): Univ Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.;Univ Porto, Dept Biol, Fac Ciencias, P-4169007 Porto, Portugal.;Univ Johannesburg, Dept Zool, ZA-2006 Auckland Pk, South Africa.

Rafati, Nima (author): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab

Villafuerte, Rafael (author): CSIC, IESA, Cordoba 14004, Spain.

Smedby, Örjan, 1956- (author): KTH,Medicinsk avbildning,KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden

Damberg, Peter (author): Karolinska Institutet

Hallböök, Finn, 1962- (author): Uppsala universitet,Medicinsk utvecklingsbiologi

Fredriksson, M (author): Karolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

Andersson, Leif (author): Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX USA; Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University

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(creator_code:org_t)

2018-06-25
2018
English.
In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 115:28, s. 7380-7385

Related links:: https://doi.org/10.1...; show more...; https://urn.kb.se/re...; https://doi.org/10.1...; https://urn.kb.se/re...; http://kipublication...; https://res.slu.se/i...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

The most characteristic feature of domestic animals is their change in behavior associated with selection for tameness. Here we show, using high-resolution brain magnetic resonance imaging in wild and domestic rabbits, that domestication reduced amygdala volume and enlarged medial prefrontal cortex volume, supporting that areas driving fear have lost volume while areas modulating negative affect have gained volume during domestication. In contrast to the localized gray matter alterations, white matter anisotropy was reduced in the corona radiata, corpus callosum, and the subcortical white matter. This suggests a compromised white matter structural integrity in projection and association fibers affecting both afferent and efferent neural flow, consistent with reduced neural processing. We propose that compared with their wild ancestors, domestic rabbits are less fearful and have an attenuated flight response because of these changes in brain architecture.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
SOCIAL SCIENCES -- Psychology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
LANTBRUKSVETENSKAPER -- Veterinärmedicin -- Medicinsk biovetenskap (hsv//swe)
AGRICULTURAL SCIENCES -- Veterinary Science -- Medical Bioscience (hsv//eng)

Keyword

rabbit
domestication
brain morphology
magnetic resonance imaging
fear

Publication and Content Type

ref (subject category)
art (subject category)

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By the author/editor: Brusini, Irene; Carneiro, Miguel; Wang, Chunliang, ...; Rubin, Carl-Joha ...; Ring, Henrik, 19 ...; Afonso, Sandra; show more...; Blanco-Aguiar, J ...; Ferrand, Nuno; Rafati, Nima; Villafuerte, Raf ...; Smedby, Örjan, 1 ...; Damberg, Peter; Hallböök, Finn, ...; Fredriksson, M; Andersson, Leif; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Neurosciences

SOCIAL SCIENCES: SOCIAL SCIENCES; and Psychology

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Radiology Nuclea ...

AGRICULTURAL SCIENCES: AGRICULTURAL SCI ...; and Veterinary Scien ...; and Medical Bioscien ...

Articles in the publication: Proceedings of t ...

By the university: Royal Institute of Technology; Uppsala University; Karolinska Institutet; Swedish University of Agricultural Sciences

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