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Changes in brain ar...
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Brusini, IreneKTH,Medicinsk avbildning,KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden
(author)
Changes in brain architecture are consistent with altered fear processing in domestic rabbits
- Article/chapterEnglish2018
Publisher, publication year, extent ...
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2018-06-25
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National Academy of Sciences,2018
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-232773
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-232773URI
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https://doi.org/10.1073/pnas.1801024115DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-355452URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:138746378URI
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https://res.slu.se/id/publ/96325URI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20180807
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The most characteristic feature of domestic animals is their change in behavior associated with selection for tameness. Here we show, using high-resolution brain magnetic resonance imaging in wild and domestic rabbits, that domestication reduced amygdala volume and enlarged medial prefrontal cortex volume, supporting that areas driving fear have lost volume while areas modulating negative affect have gained volume during domestication. In contrast to the localized gray matter alterations, white matter anisotropy was reduced in the corona radiata, corpus callosum, and the subcortical white matter. This suggests a compromised white matter structural integrity in projection and association fibers affecting both afferent and efferent neural flow, consistent with reduced neural processing. We propose that compared with their wild ancestors, domestic rabbits are less fearful and have an attenuated flight response because of these changes in brain architecture.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Carneiro, MiguelUniv Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.;Univ Porto, Dept Biol, Fac Ciencias, P-4169007 Porto, Portugal.
(author)
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Wang, Chunliang,1980-KTH,Medicinsk avbildning,KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden(Swepub:kth)u1tbkeej
(author)
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Rubin, Carl-JohanUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)carub021
(author)
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Ring, Henrik,1981-Uppsala universitet,Medicinsk utvecklingsbiologi(Swepub:uu)henri246
(author)
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Afonso, SandraUniv Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.
(author)
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Blanco-Aguiar, Jose A.Univ Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.;CSIC, Inst Invest Recursos Cineget IREC, Ciudad Real 13005, Spain.;UCLM, CSIC, Ciudad Real 13005, Spain.
(author)
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Ferrand, NunoUniv Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, P-4485661 Vairao, Portugal.;Univ Porto, Dept Biol, Fac Ciencias, P-4169007 Porto, Portugal.;Univ Johannesburg, Dept Zool, ZA-2006 Auckland Pk, South Africa.
(author)
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Rafati, NimaUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)nimra236
(author)
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Villafuerte, RafaelCSIC, IESA, Cordoba 14004, Spain.
(author)
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Smedby, Örjan,1956-KTH,Medicinsk avbildning,KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden(Swepub:kth)u1vc2uzb
(author)
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Damberg, PeterKarolinska Institutet
(author)
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Hallböök, Finn,1962-Uppsala universitet,Medicinsk utvecklingsbiologi(Swepub:uu)finnhb
(author)
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Fredriksson, MKarolinska Institutet,Uppsala universitet,Institutionen för psykologi,Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden(Swepub:uu)matsfred
(author)
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Andersson, LeifSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX USA; Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University(Swepub:slu)48730
(author)
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KTHMedicinsk avbildning
(creator_code:org_t)
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Sveriges lantbruksuniversitet
Related titles
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In:Proceedings of the National Academy of Sciences of the United States of America: National Academy of Sciences115:28, s. 7380-73850027-84241091-6490
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- By the author/editor
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Brusini, Irene
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Carneiro, Miguel
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Wang, Chunliang, ...
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Rubin, Carl-Joha ...
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Ring, Henrik, 19 ...
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Afonso, Sandra
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Blanco-Aguiar, J ...
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Ferrand, Nuno
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Rafati, Nima
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Villafuerte, Raf ...
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Smedby, Örjan, 1 ...
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Damberg, Peter
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Hallböök, Finn, ...
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Fredriksson, M
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Andersson, Leif
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- MEDICAL AND HEALTH SCIENCES
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SOCIAL SCIENCES
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Royal Institute of Technology
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Uppsala University
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Karolinska Institutet
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Swedish University of Agricultural Sciences