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Stereotypic Immune ...
Stereotypic Immune System Development in Newborn Children
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- Olin, Axel (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, S-17121 Solna, Sweden.
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- Henckel, Ewa (author)
- Karolinska Institutet
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- Chen, Yang (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, S-17121 Solna, Sweden.
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- Lakshmikanth, Tadepally (author)
- Karolinska Institutet
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- Pou, Christian (author)
- Karolinska Institutet
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- Mikes, Jaromir (author)
- Karolinska Institutet
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- Gustafsson, Anna (author)
- Karolinska Institutet
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- Bernhardsson, Anna Karin (author)
- Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, S-17121 Solna, Sweden.;Karolinska Univ Hosp, Dept Neonatol, S-17176 Solna, Sweden.
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- Zhang, Cheng (author)
- KTH,Science for Life Laboratory, SciLifeLab
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- Bohlin, Kajsa (author)
- Karolinska Institutet
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- Brodin, Petter (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, S-17121 Solna, Sweden (creator_code:org_t)
- CELL PRESS, 2018
- 2018
- English.
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In: Cell. - : CELL PRESS. - 0092-8674 .- 1097-4172. ; 174:5, s. 1277-
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Abstract
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- Epidemiological data suggest that early life exposures are key determinants of immune-mediated disease later in life. Young children are also particularly susceptible to infections, warranting more analyses of immune system development early in life. Such analyses mostly have been performed in mouse models or human cord blood samples, but these cannot account for the complex environmental exposures influencing human newborns after birth. Here, we performed longitudinal analyses in 100 newborn children, sampled up to 4 times during their first 3 months of life. From 100 mu L of blood, we analyze the development of 58 immune cell populations by mass cytometry and 267 plasma proteins by immunoassays, uncovering drastic changes not predictable from cord blood measurements but following a stereotypic pattern. Preterm and term children differ at birth but converge onto a shared trajectory, seemingly driven by microbial interactions and hampered by early gut bacterial dysbiosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cell
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- By the author/editor
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Olin, Axel
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Henckel, Ewa
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Chen, Yang
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Lakshmikanth, Ta ...
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Pou, Christian
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Mikes, Jaromir
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Gustafsson, Anna
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Bernhardsson, An ...
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Zhang, Cheng
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Bohlin, Kajsa
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Brodin, Petter
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Pediatrics
- Articles in the publication
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Cell
- By the university
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Royal Institute of Technology
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Karolinska Institutet