Genome-based proteomics

• Protein-protein interactions play crucial roles in various biological pathways and functions. Therefore, the characterization of protein levels and also the network of interactions within an organism would contribute considerably to the understanding of life. The availability of the human genome sequence has created a range of new possibilities for biomedical research. A crucial challenge is to utilize the genetic information for better understanding of protein distribution and function in normal as well as in pathological biological processes. In this review, we have focused on different platforms used for systematic genome-based proteome analyses. These technologies are in many ways complementary and should be seen as various ways to elucidate different functions of the proteome.

Subject headings

NATURVETENSKAP  -- Biologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Keyword

genomics

protein interactions

protein localization

protein modifications

proteomics

review

protein-protein interactions

saccharomyces-cerevisiae

structural genomics

mass-spectrometry

subcellular-localization

global analysis

genetic system

yeast proteome

beta-lactamase

in-vivo

Publication and Content Type

ref (subject category)

art (subject category)