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Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
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- Matic, L. P. (author)
- Karolinska Institutet,Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden.
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- Iglesias, Maria Jesus (author)
- KTH,Science for Life Laboratory, SciLifeLab,Proteomik och nanobioteknologi,Royal Inst Technol, Sch Biotechnol, Dept Prote, Sci Life Lab, Stockholm, Sweden.
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- Vesterlund, M. (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Canc Prote, Stockholm, Sweden.
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- Karolinska Institutet Karolinska Inst, Dept Mol Med & Surg, L8 03, SE-17176 Stockholm, Sweden (creator_code:org_t)
- Elsevier BV, 2018
- 2018
- English.
- In: JACC: Basic to Translational Science. - : Elsevier BV. - 2452-302X. ; 3:4, s. 464-480
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Clinical tools to identify individuals with unstable atherosclerotic lesions are required to improve prevention of myocardial infarction and ischemic stroke. Here, a systems-based analysis of atherosclerotic plaques and plasma from patients undergoing carotid endarterectomy for stroke prevention was used to identify molecular signatures with a causal relationship to disease. Local plasma collected in the lesion proximity following clamping prior to arteriotomy was profiled together with matched peripheral plasma. This translational workflow identified biliverdin reductase B as a novel marker of intraplaque hemorrhage and unstable carotid atherosclerosis, which should be investigated as a potential predictive biomarker for cardiovascular events in larger cohorts.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- atherosclerosis
- biomarkers
- intraplaque hemorrhage
- omics analyses
- translational studies
Publication and Content Type
- ref (subject category)
- art (subject category)
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