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Stabilized Cyclic P...
Stabilized Cyclic Peptides as Scavengers of Autoantibodies : Neutralization of Anticitrullinated Protein/Peptide Antibodies in Rheumatoid Arthritis
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- Gunasekera, Sunithi, 1977- (author)
- Uppsala universitet,Farmakognosi
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- Fernandes-Cerqueira, C. (author)
- Karolinska Institutet
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- Wennmalm, Stefan, 1970- (author)
- KTH,Experimentell biomolekylär fysik,Science for Life Laboratory, SciLifeLab,Royal Inst Technol KTH, Scilifelab, Appl Phys, Expt Biomol Phys, Tomtebodavagen 23, S-17165 Stockholm, Sweden
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- Wähämaa, H. (author)
- Karolinska Institutet
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- Sommarin, Y. (author)
- Eurodiagnost AB, S-21224 Malmo, Sweden
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- Catrina, A. I. (author)
- Karolinska Institutet
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- Jakobsson, P. -J (author)
- Karolinska Institutet
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- Göransson, Ulf, 1970- (author)
- Uppsala universitet,Farmakognosi
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(creator_code:org_t)
- 2018-04-09
- 2018
- English.
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In: ACS Chemical Biology. - : American Chemical Society (ACS). - 1554-8929 .- 1554-8937. ; 13:6, s. 1525-1535
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Subject headings
Close
- The occurrence of autoantibodies is a hallmark of rheumatoid arthritis, specifically those autoantibodies targeting proteins containing the arginine-derived amino acid citrulline. There is strong evidence showing that the occurrence of anticitrullinated protein/peptide antibodies (ACPA) are involved in disease progression, and ACPA was recently shown to induce pain in animals. Here, we explore a novel concept useful for research, diagnostics, and possibly therapy of autoimmune diseases, namely, to directly target and neutralize autoantibodies using peptide binders. A high-affinity peptide-based scavenger of ACPA was developed by grafting a citrullinated epitope derived from human fibrinogen into a naturally occurring stable peptide scaffold. The best scavenger comprises the truncated epitope α-fibrinogen, [Cit573]fib(566-580), grafted into the scaffold sunflower trypsin inhibitor-1, SFTI-1. The final peptide demonstrates low nanomolar apparent affinity and superior stability.
Subject headings
- NATURVETENSKAP -- Kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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