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The Human Endometri...
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Zieba, AgataUppsala universitet,Molekylära verktyg
(author)
The Human Endometrium-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling
- Article/chapterEnglish2015
Publisher, publication year, extent ...
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MARY ANN LIEBERT, INC,2015
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-243643
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-243643URI
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https://doi.org/10.1089/omi.2015.0115DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269256URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20190304
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The human uterus includes the complex endometrial mucosa, the endometrium that undergoes dynamic, hormone-dependent alterations throughout the life of fertile females. Here we have combined a genome-wide transcriptomics analysis with immunohistochemistry-based protein profiling to analyze gene expression patterns in the normal endometrium. Human endometrial tissues from five women were used for deep sequencing (RNA-Seq). The mRNA and protein expression data from the endometrium were compared to 31 (RNA) and 44 (protein) other normal tissue types, to identify genes with elevated expression in the endometrium and to localize the expression of corresponding proteins at a cellular resolution. Based on the expression levels of transcripts, we could classify all putative human protein coding genes into categories defined by expression patterns and found altogether 101 genes that showed an elevated pattern of expression in the endometrium, with only four genes showing more than five-fold higher expression levels in the endometrium compared to other tissues. In conclusion, our analysis based on transcriptomics and antibody-based protein profiling reports here comprehensive lists of genes with elevated expression levels in the endometrium, providing important starting points for a better molecular understanding of human reproductive biology and disease.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sjöstedt, EvelinaKTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u12iezpl
(author)
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Olovsson, MattsUppsala universitet,Obstetrik & gynekologi,Uppsala Univ, Dept Womens & Childrens Hlth, S-75185 Uppsala, Sweden.(Swepub:uu)mattolov
(author)
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Fagerberg, LinnKTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u1dglfid
(author)
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Hallström, Björn M.KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u1ih19oh
(author)
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Oskarsson, LindaUppsala universitet,Institutionen för immunologi, genetik och patologi
(author)
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Edlund, KarolinaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)kaedl086
(author)
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Tolf, AnnaUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)annto745
(author)
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Uhlén, MathiasKTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden.(Swepub:kth)u1dulvmw
(author)
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Pontén, FredrikUppsala universitet,Institutionen för immunologi, genetik och patologi(Swepub:uu)fredpont
(author)
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Uppsala universitetMolekylära verktyg
(creator_code:org_t)
Related titles
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In:Omics: MARY ANN LIEBERT, INC19:11, s. 659-6681536-23101557-8100
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Zieba, Agata
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Sjöstedt, Evelin ...
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Olovsson, Matts
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Fagerberg, Linn
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Hallström, Björn ...
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Oskarsson, Linda
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Edlund, Karolina
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Tolf, Anna
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Uhlén, Mathias
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Pontén, Fredrik
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