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Transcriptomics of ...
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Das, SarbashisUppsala universitet,Molekylärbiologi,Science for Life Laboratory, SciLifeLab
(author)
Transcriptomics of cardiac biopsies reveals differences in patients with or without diagnostic parameters for heart failure with preserved ejection fraction
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-02-28
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NATURE PUBLISHING GROUP,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-246254
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-246254URI
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https://doi.org/10.1038/s41598-019-39445-2DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-379578URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:140393326URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20190401
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Heart failure affects 2-3% of adult Western population. Prevalence of heart failure with preserved left ventricular (LV) ejection fraction (HFpEF) increases. Studies suggest HFpEF patients to have altered myocardial structure and functional changes such as incomplete relaxation and increased cardiac stiffness. We hypothesised that patients undergoing elective coronary bypass surgery (CABG) with HFpEF characteristics would show distinctive gene expression compared to patients with normal LV physiology. Myocardial biopsies for mRNA expression analysis were obtained from sixteen patients with LV ejection fraction >= 45%. Five out of 16 patients (31%) had echocardiographic characteristics and increased NTproBNP levels indicative of HFpEF and this group was used as HFpEF proxy, while 11 patients had Normal LV physiology. Utilising principal component analysis, the gene expression data clustered into two groups, corresponding to HFpEF proxy and Normal physiology, and 743 differentially expressed genes were identified. The associated top biological functions were cardiac muscle contraction, oxidative phosphorylation, cellular remodelling and matrix organisation. Our results also indicate that upstream regulatory events, including inhibition of transcription factors STAT4, SRF and TP53, and activation of transcription repressors HEY2 and KDM5A, could provide explanatory mechanisms to observed gene expression differences and ultimately cardiac dysfunction in the HFpEF proxy group.
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Frisk, ChristofferUppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab(Swepub:uu)chrfr742
(author)
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Eriksson, Maria J.Karolinska Institutet
(author)
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Walentinsson, AnnaAstraZeneca, IMED Biotech Unit, Translat Sci Cardiovasc Renal & Metab Dis, S-43183 Gothenburg, Sweden.
(author)
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Corbascio, MatthiasKarolinska Institutet
(author)
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Hage, CamillaKarolinska Institutet
(author)
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Kumar, ChanchalAstraZeneca, IMED Biotech Unit, Translat Sci Cardiovasc Renal & Metab Dis, S-43183 Gothenburg, Sweden.;Karolinska Inst, ICMC, Dept Med, S-14157 Huddinge, Sweden.
(author)
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Asp, MichaelaKTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Royal Inst Technol, Sci Life Lab, S-17121 Stockholm, Sweden(Swepub:kth)u1a76sfq
(author)
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Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Royal Inst Technol, Sci Life Lab, S-17121 Stockholm, Sweden(Swepub:kth)u1qkn9kw
(author)
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Maret, EvaKarolinska Univ Hosp, Dept Clin Physiol, S-17176 Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, S-17177 Stockholm, Sweden.
(author)
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Persson, HansKarolinska Institutet
(author)
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Linde, CeciliaKarolinska Institutet
(author)
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Persson, BengtUppsala universitet,Science for Life Laboratory, SciLifeLab,Beräkningsbiologi och bioinformatik,Karolinska Inst, Dept Med Biochem & Biophys, Sci Life Lab, S-17177 Stockholm, Sweden(Swepub:uu)benpe457
(author)
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Uppsala universitetMolekylärbiologi
(creator_code:org_t)
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In:Scientific Reports: NATURE PUBLISHING GROUP92045-2322
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Das, Sarbashis
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Frisk, Christoff ...
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Eriksson, Maria ...
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Walentinsson, An ...
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Corbascio, Matth ...
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Hage, Camilla
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Kumar, Chanchal
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Asp, Michaela
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Lundeberg, Joaki ...
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Maret, Eva
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Persson, Hans
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Linde, Cecilia
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Persson, Bengt
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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Royal Institute of Technology
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Karolinska Institutet