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Breast cancer quant...
Breast cancer quantitative proteome and proteogenomic landscape
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- Johansson, Henrik J. (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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- Socciarelli, Fabio (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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- Vacanti, Nathaniel M. (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden.;Cornell Univ, Div Nutrit Sci, Ithaca, NY 14853 USA.
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- Haugen, Mads H. (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.
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- Zhu, Yafeng (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden.
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- Siavelis, Ioannis (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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- Fernandez-Woodbridge, Alejandro (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden.
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- Aure, Miriam R. (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.
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- Sennblad, Bengt (author)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Vesterlund, Mattias (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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- Branca, Rui M. (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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- Orre, Lukas M. (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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- Huss, Mikael (author)
- Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),Stockholm Univ, Sci Life Lab, Dept Biochem & Biophys, Natl Bioinformat Infrastruct Sweden, S-17121 Solna, Sweden.
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- Fredlund, Erik (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden.
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- Beraki, Elsa (author)
- Oslo Univ Hosp, Dept Pathol, N-0424 Oslo, Norway.
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- Garred, Oystein (author)
- Oslo Univ Hosp, Dept Pathol, N-0424 Oslo, Norway.
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- Boekel, Jorrit (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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- Sauer, Torill (author)
- Akershus Univ Hosp, Dept Pathol, N-1478 Lorenskog, Norway.;Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.
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- Zhao, Wei (author)
- Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77230 USA.
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- Nord, Silje (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.
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- Hoglander, Elen K. (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.
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- Jans, Daniel C. (author)
- KTH,Tillämpad fysik,KTH Royal Inst Technol, Dept Appl Phys, S-17121 Solna, Sweden
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- Brismar, Hjalmar (author)
- Karolinska Institutet,KTH,Tillämpad fysik,KTH Royal Inst Technol, Dept Appl Phys, S-17121 Solna, Sweden;Karolinska Inst, Dept Womenss & Childrens Hlth, S-17121 Solna, Sweden
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- Haukaas, Tonje H. (author)
- Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, N-7491 Trondheim, Norway.
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- Bathen, Tone F. (author)
- Norwegian Univ Sci & Technol NTNU, Dept Circulat & Med Imaging, N-7491 Trondheim, Norway.
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- Schlichting, Ellen (author)
- Oslo Univ Hosp, Dept Canc, Sect Breast & Endocrine Surg, Div Surg Canc & Transplantat Med, N-0424 Oslo, Norway.
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- Naume, Bjorn (author)
- Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.;Oslo Univ Hosp, Div Surg & Canc & Transplantat Med, Dept Oncol, N-0424 Oslo, Norway.
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- Geisler, Juergen (author)
- Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.;Akershus Univ Hosp, Dept Oncol, N-1478 Lorenskog, Norway.;Akershus Univ Hosp, Div Med, N-1478 Lorenskog, Norway.
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- Hofvind, Solveig (author)
- Canc Registry Norway, N-0379 Oslo, Norway.;Oslo & Akershus Univ, Coll Appl Sci, Fac Hlth Sci, N-0130 Oslo, Norway.
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- Engebraten, Olav (author)
- Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.;Oslo Univ Hosp, Div Surg & Canc & Transplantat Med, Dept Oncol, N-0424 Oslo, Norway.;Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, N-0379 Oslo, Norway.
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- Geitvik, Gry Aarum (author)
- Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Canc Genet, N-0379 Oslo, Norway.
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- Langerod, Anita (author)
- Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Canc Genet, N-0379 Oslo, Norway.
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- Karesen, Rolf (author)
- Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.;Oslo Univ Hosp, Div Surg Canc & Transplantat, Dept Breast & Endocrine Surg, N-0379 Oslo, Norway.
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- Maelandsmo, Gunhild Mari (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, N-0379 Oslo, Norway.;Univ Tromso, Fac Hlth Sci, Dept Pharm, N-9010 Tromso, Norway.
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- Sorlie, Therese (author)
- Oslo Univ Hosp, Norwegian Radium Hosp, Inst Canc Res, Dept Canc Genet, N-0379 Oslo, Norway.
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- Skjerven, Helle Kristine (author)
- Vestre Viken Hosp Trust, Dept Breast & Endocrine Surg, Breast & Endocrine Surg, N-3004 Drammen, Norway.
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- Park, Daehoon (author)
- Vestre Viken Hosp Trust, Dept Pathol, N-3004 Drammen, Norway.
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- Hartman-Johnsen, Olaf-Johan (author)
- Ostfold Hosp, N-1714 Ostfold, Norway.
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- Luders, Torben (author)
- Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.;Akershus Univ Hosp, Div Med, Dept Clin Mol Biol & Lab Sci EpiGen, N-1478 Lorenskog, Norway.
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- Borgen, Elin (author)
- Oslo Univ Hosp, Dept Pathol, N-0424 Oslo, Norway.
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- Kristensen, Vessela N. (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.;Akershus Univ Hosp, Div Med, Dept Clin Mol Biol & Lab Sci EpiGen, N-1478 Lorenskog, Norway.
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- Russnes, Hege G. (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.
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- Lingjaerde, Ole Christian (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Ctr Canc Biomed, N-0424 Oslo, Norway.
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- Mills, Gordon B. (author)
- Univ Texas MD Anderson Canc Ctr, Dept Syst Biol, Houston, TX 77230 USA.
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- Sahlberg, Kristine K. (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.;Vestre Viken Hosp Trust, Dept Res, N-3004 Drammen, Norway.
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- Borresen-Dale, Anne-Lise (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, N-0424 Oslo, Norway.;Univ Oslo, Inst Clin Med, N-0318 Oslo, Norway.
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- Lehtio, Janne (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, S-17121 Solna, Sweden
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(creator_code:org_t)
- 2019-04-08
- 2019
- English.
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In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
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Abstract
Subject headings
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- In the preceding decades, molecular characterization has revolutionized breast cancer (BC) research and therapeutic approaches. Presented herein, an unbiased analysis of breast tumor proteomes, inclusive of 9995 proteins quantified across all tumors, for the first time recapitulates BC subtypes. Additionally, poor-prognosis basal-like and luminal B tumors are further subdivided by immune component infiltration, suggesting the current classification is incomplete. Proteome-based networks distinguish functional protein modules for breast tumor groups, with co-expression of EGFR and MET marking ductal carcinoma in situ regions of normal-like tumors and lending to a more accurate classification of this poorly defined subtype. Genes included within prognostic mRNA panels have significantly higher than average mRNA-protein correlations, and gene copy number alterations are dampened at the protein-level; underscoring the value of proteome quantification for prognostication and phenotypic classification. Furthermore, protein products mapping to non-coding genomic regions are identified; highlighting a potential new class of tumor-specific immunotherapeutic targets.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Johansson, Henri ...
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Socciarelli, Fab ...
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Vacanti, Nathani ...
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Haugen, Mads H.
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Zhu, Yafeng
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Siavelis, Ioanni ...
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show more...
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Fernandez-Woodbr ...
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Aure, Miriam R.
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Sennblad, Bengt
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Vesterlund, Matt ...
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Branca, Rui M.
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Orre, Lukas M.
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Huss, Mikael
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Fredlund, Erik
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Beraki, Elsa
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Garred, Oystein
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Boekel, Jorrit
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Sauer, Torill
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Zhao, Wei
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Nord, Silje
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Hoglander, Elen ...
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Jans, Daniel C.
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Brismar, Hjalmar
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Haukaas, Tonje H ...
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Bathen, Tone F.
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Schlichting, Ell ...
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Naume, Bjorn
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Geisler, Juergen
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Hofvind, Solveig
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Engebraten, Olav
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Geitvik, Gry Aar ...
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Langerod, Anita
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Karesen, Rolf
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Maelandsmo, Gunh ...
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Sorlie, Therese
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Skjerven, Helle ...
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Park, Daehoon
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Hartman-Johnsen, ...
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Luders, Torben
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Borgen, Elin
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Kristensen, Vess ...
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Russnes, Hege G.
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Lingjaerde, Ole ...
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Mills, Gordon B.
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Sahlberg, Kristi ...
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Borresen-Dale, A ...
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Lehtio, Janne
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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Nature Communica ...
- By the university
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Royal Institute of Technology
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Stockholm University
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Karolinska Institutet
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Uppsala University