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Affibody-Mediated S...
Affibody-Mediated Sequestration of Amyloid beta Demonstrates Preventive Efficacy in a Transgenic Alzheimer's Disease Mouse Model
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- Boutajangout, Allal (author)
- NYU, Ctr Cognit Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Psychiat, Langone Hlth, 550 1St Ave, New York, NY 10016 USA.;NYU, Langone Med Ctr, Dept Physiol & Neurosci, New York, NY USA.
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- Lindberg, Hanna (author)
- KTH,Proteinvetenskap
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- Awwad, Abdulaziz (author)
- King Abdulaziz Univ, Sch Med, Jeddah, Saudi Arabia.
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- Paul, Arun (author)
- NYU, Ctr Cognit Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Neurol, Langone Hlth, New York, NY 10016 USA.
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- Baitalmal, Rabaa (author)
- NYU, Ctr Cognit Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Neurol, Langone Hlth, New York, NY 10016 USA.
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- Almokyad, Ismail (author)
- NYU, Ctr Cognit Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Neurol, Langone Hlth, New York, NY 10016 USA.
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- Hoiden-Guthenberg, Ingmarie (author)
- Affibody AB, Solna, Sweden.
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- Gunneriusson, Elin (author)
- Affibody AB, Solna, Sweden.
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- Frejd, Fredrik Y. (author)
- Affibody AB, Solna, Sweden.
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- Härd, Torleif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för Kemi och Bioteknologi,The Department of Chemistry and Biotechnology
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- Löfblom, John (author)
- KTH,Proteinvetenskap
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- Ståhl, Stefan (author)
- KTH,Proteinvetenskap
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- Wisniewski, Thomas (author)
- NYU, Ctr Cognit Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Psychiat, Langone Hlth, 550 1St Ave, New York, NY 10016 USA.;NYU, Sch Med, Dept Pathol, New York, NY 10016 USA.
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NYU, Ctr Cognit Neurol, Langone Hlth, New York, NY 10016 USA;NYU, Dept Neurol, Langone Hlth, New York, NY 10016 USA.;NYU, Dept Psychiat, Langone Hlth, 550 1St Ave, New York, NY 10016 USA.;NYU, Langone Med Ctr, Dept Physiol & Neurosci, New York, NY USA. Proteinvetenskap (creator_code:org_t)
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- 2019-03-22
- 2019
- English.
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In: Frontiers in Aging Neuroscience. - : Frontiers Media S.A.. - 1663-4365. ; 11
- Related links:
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https://www.frontier...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://res.slu.se/i...
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Abstract
Subject headings
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- Different strategies for treatment and prevention of Alzheimer's disease (AD) are currently under investigation, including passive immunization with anti-amyloid beta (anti-A beta) monoclonal antibodies (mAbs). Here, we investigate the therapeutic potential of a novel type of A beta-targeting agent based on an affibody molecule with fundamentally different properties to mAbs. We generated a therapeutic candidate, denoted Z(SYM73)-albumin-binding domain (ABD; 16.8 kDa), by genetic linkage of the dimeric Z(SYM73) affibody for sequestering of monomeric A beta-peptides and an ABD for extension of its in vivo half-life. Amyloid precursor protein (APP)/PS1 transgenic AD mice were administered with Z(SYM73)-ABD, followed by behavioral examination and immunohistochemistry. Results demonstrated rescued cognitive functions and significantly lower amyloid burden in the treated animals compared to controls. No toxicological symptoms or immunology-related side-effects were observed. To our knowledge, this is the first reported in vivo investigation of a systemically delivered scaffold protein against monomeric A beta, demonstrating a therapeutic potential for prevention of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- affibody molecule
- amyloid beta (A beta)
- behavior
- histology
- immunotherapy
- transgenic mice
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Boutajangout, Al ...
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Lindberg, Hanna
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Awwad, Abdulaziz
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Paul, Arun
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Baitalmal, Rabaa
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Almokyad, Ismail
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show more...
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Hoiden-Guthenber ...
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Gunneriusson, El ...
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Frejd, Fredrik Y ...
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Härd, Torleif
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Löfblom, John
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Ståhl, Stefan
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Wisniewski, Thom ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Geriatrics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Frontiers in Agi ...
- By the university
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Royal Institute of Technology
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Swedish University of Agricultural Sciences