SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:kth-254028"
 

Search: onr:"swepub:oai:DiVA.org:kth-254028" > Efficacy of copolym...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration

Munir, Arooj (author)
Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
Doskeland, Anne (author)
Univ Bergen, Dept Biomed, Bergen, Norway.
Avery, Steven J. (author)
Cardiff Univ, Dept Oral & Biomed Sci, Sch Dent, Cardiff, S Glam, Wales.;CITER, Cardiff, S Glam, Wales.
show more...
Fuoco, Tiziana, PhD, 1986- (author)
KTH,Fiber- och polymerteknologi
Mohamed-Ahmed, Samih (author)
Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
Lygre, Henning (author)
Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
Finne Wistrand, Anna, 1976- (author)
KTH,Fiber- och polymerteknologi,sDept Fibre & Polymer Technol, Stockholm, Sweden.
Sloan, Alastair J. (author)
Cardiff Univ, Dept Oral & Biomed Sci, Sch Dent, Cardiff, S Glam, Wales.;CITER, Cardiff, S Glam, Wales.
Waddington, Rachel J. (author)
Cardiff Univ, Dept Oral & Biomed Sci, Sch Dent, Cardiff, S Glam, Wales.;CITER, Cardiff, S Glam, Wales.
Mustafa, Kamal (author)
Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
Suliman, Salwa (author)
Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway.
show less...
Univ Bergen, Ctr Clin Dent Res, Dept Clin Dent, Fac Med, N-5009 Bergen, Norway Univ Bergen, Dept Biomed, Bergen, Norway. (creator_code:org_t)
2019-05-31
2019
English.
In: Journal of Tissue Engineering. - : SAGE PUBLICATIONS INC. - 2041-7314. ; 10
Related links:
https://doi.org/10.1...
show more...
https://doi.org/10.1...
https://urn.kb.se/re...
https://doi.org/10.1...
show less...
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Poly(L-lactide-co-epsilon-caprolactone) scaffolds were functionalised by 10 or 20 mu g/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after 7 and 21 days were studied. A total of 390 proteins were identified by mass spectrometry. Bone regeneration proteins showed initial burst of release. Human bone marrow stromal cells were cultured on scaffolds physisorbed with 20 mu g/mL and cultured in basal medium (DDM group) or physisorbed and cultured in osteogenic medium or cultured on non-functionalised scaffolds in osteogenic medium. The human bone marrow stromal cells proliferated less in demineralised dentine matrix group and activated ERK/1/2 after both time points. Cells on DDM group showed highest expression of IL-6 and IL-8 at 7 days and expressed higher collagen type 1 alpha 2, SPP1 and bone morphogenetic protein-2 until 21 days. Extracellular protein revealed higher collagen type 1 and bone morphogenetic protein-2 at 21 days in demineralised dentine matrix group. Cells on DDM group showed signs of mineralisation. The functionalised scaffolds were able to stimulate osteogenic differentiation of human bone marrow stromal cells.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Keyword

Growth factor
mesenchymal stem cell
bone tissue engineering
drug delivery
functionalisation

Publication and Content Type

ref (subject category)
art (subject category)

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view