onr:"swepub:oai:DiVA.org:kth-254498"
Search: onr:"swepub:oai:DiVA.org:kth-254498" > Hypoxia-enhanced Bl...
- 1 of 1
- Previous record
- Next record
- To hitlist
Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function and shuttling of drugs and antibodies
-
- Park, Tae-Eun (author)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.;UNIST, UNIST Gil 50, Ulsan 44919, South Korea.
-
- Mustafaoglu, Nur (author)
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA.
-
- Herland, Anna (author)
- Karolinska Institutet,KTH,Mikro- och nanosystemteknik,Harvard Univ, USA ;Karolinska Inst, Swedish Med Nanosci Ctr, Dept Neurosci, Stockholm, Sweden.
- show more...
- show less...
- Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA;UNIST, UNIST Gil 50, Ulsan 44919, South Korea. Harvard Univ, Wyss Inst Biol Inspired Engn, Boston, MA 02115 USA. (creator_code:org_t)
- 2019-06-13
- 2019
- English.
- In: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 10
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- The high selectivity of the human blood-brain barrier (BBB) restricts delivery of many pharmaceuticals and therapeutic antibodies to the central nervous system. Here, we describe an in vitro microfluidic organ-on-a-chip BBB model lined by induced pluripotent stem cell-derived human brain microvascular endothelium interfaced with primary human brain astrocytes and pericytes that recapitulates the high level of barrier function of the in vivo human BBB for at least one week in culture. The endothelium expresses high levels of tight junction proteins and functional efflux pumps, and it displays selective transcytosis of peptides and antibodies previously observed in vivo. Increased barrier functionality was accomplished using a developmentally-inspired induction protocol that includes a period of differentiation under hypoxic conditions. This enhanced BBB Chip may therefore represent a new in vitro tool for development and validation of delivery systems that transport drugs and therapeutic antibodies across the human BBB.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Nanoteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Nano-technology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Nature Communications (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Park, Tae-Eun
- Mustafaoglu, Nur
- Herland, Anna
- Hasselkus, Ryan
- Mannix, Robert
- FitzGerald, Edwa ...
- show more...
- Prantil-Baun, Ra ...
- Watters, Alexand ...
- Henry, Olivier
- Benz, Maximilian
- Sanchez, Henry
- McCrea, Heather ...
- Goumnerova, Lili ...
- Song, Hannah W.
- Palecek, Sean P.
- Shusta, Eric
- Ingber, Donald E ...
- show less...
- About the subject
-
- ENGINEERING AND TECHNOLOGY
- ENGINEERING AND ...
- and Nano technology
- Articles in the publication
- Nature Communica ...
- By the university
- Royal Institute of Technology
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
