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- Yassin, Mohammed A.KTH,Fiber- och polymerteknologi (author)
3D and Porous RGDC-Functionalized Polyester-Based Scaffolds as a Niche to Induce Osteogenic Differentiation of Human Bone Marrow Stem Cells
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- 2019-05-03
- WILEY-V C H VERLAG GMBH,2019
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-255207
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-255207URI
- https://doi.org/10.1002/mabi.201900049DOI
Supplementary language notes
- Language:English
- Summary in:English
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Notes
- QC 20190904
- Polyester-based scaffolds covalently functionalized with arginine-glycine-aspartic acid-cysteine (RGDC) peptide sequences support the proliferation and osteogenic differentiation of stem cells. The aim is to create an optimized 3D niche to sustain human bone marrow stem cell (hBMSC) viability and osteogenic commitment, without reliance on differentiation media. Scaffolds consisting of poly(lactide-co-trimethylene carbonate), poly(LA-co-TMC), and functionalized poly(lactide) copolymers with pendant thiol groups are prepared by salt-leaching technique. The availability of functional groups on scaffold surfaces allows for an easy and straightforward method to covalently attach RGDC peptide motifs without affecting the polymerization degree. The strategy enables the chemical binding of bioactive motifs on the surfaces of 3D scaffolds and avoids conventional methods that require harsh conditions. Gene and protein levels and mineral deposition indicate the osteogenic commitment of hBMSC cultured on the RGDC functionalized surfaces. The osteogenic commitment of hBMSC is enhanced on functionalized surfaces compared with nonfunctionalized surfaces and without supplementing media with osteogenic factors. Poly(LA-co-TMC) scaffolds have potential as scaffolds for osteoblast culture and bone grafts. Furthermore, these results contribute to the development of biomimetic materials and allow a deeper comprehension of the importance of RGD peptides on stem cell transition toward osteoblastic lineage.
Subject headings and genre
- NATURVETENSKAP Kemi Polymerkemi hsv//swe
- NATURAL SCIENCES Chemical Sciences Polymer Chemistry hsv//eng
- degradable polymer
- human bone marrow stem cells
- poly(l-lactide-co-trimethylene carbonate)
- RGDC
Added entries (persons, corporate bodies, meetings, titles ...)
- Fuoco, Tiziana,PhD,1986-KTH,Fiber- och polymerteknologi(Swepub:kth)u1m7d0c7 (author)
- Mohamed-Ahmed, SamihDept Clin Dent, Arstadveien 19, N-5009 Bergen, Norway. (author)
- Mustafa, KamalDept Clin Dent, Arstadveien 19, N-5009 Bergen, Norway. (author)
- Finne Wistrand, Anna,1976-KTH,Fiber- och polymerteknologi(Swepub:kth)u17gwfv7 (author)
- KTHFiber- och polymerteknologi (creator_code:org_t)
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- In:Macromolecular Bioscience: WILEY-V C H VERLAG GMBH19:61616-51871616-5195
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