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A rapid smartphone-...
A rapid smartphone-based lactate dehydrogenase test for neonatal diagnostics at the point of care
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- Halvorsen, Cecilia Pegelow (author)
- Karolinska Institutet,Karolinska Inst, Dept Clin Res & Educ, Sodersjukhuset, Stockholm, Sweden;Sachs Children & Youth Hosp, Neonatal Unit, Stockholm, Sweden
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- Olson, Linus (author)
- Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Stockholm, Sweden;Karolinska Inst, Dept Publ Hlth Sci, Stockholm, Sweden;TRAC Sweden Vietnam, Hanoi, Vietnam
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- Araujo, Ana Catarina (author)
- Calmark Sweden AB, Stockholm, Sweden.
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- Karlsson, Mathias (author)
- Uppsala universitet,Klinisk kemi,Calmark Sweden AB, Stockholm, Sweden
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- Nguyen, Trang Thi (author)
- Vietnam Natl Childrens Hosp, Neonatal Intens Care Unit, Hanoi, Vietnam;Res Inst Child Hlth, Hanoi, Vietnam
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- Khu, Dung T. K. (author)
- TRAC Sweden Vietnam, Hanoi, Vietnam.;Vietnam Natl Childrens Hosp, Neonatal Intens Care Unit, Hanoi, Vietnam.
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- Le, Ha T. T. (author)
- Vietnam Natl Childrens Hosp, Neonatal Intens Care Unit, Hanoi, Vietnam.;Res Inst Child Hlth, Hanoi, Vietnam.
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- Nguyen, Hoa T. B. (author)
- Vietnam Natl Childrens Hosp, Neonatal Intens Care Unit, Hanoi, Vietnam.;Res Inst Child Hlth, Hanoi, Vietnam.
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- Winbladh, Birger (author)
- Karolinska Inst, Dept Clin Res & Educ, Sodersjukhuset, Stockholm, Sweden.
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- Russom, Aman, Assoc.Prof. (author)
- KTH,Proteinvetenskap,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Div Nanobiotechnol, Dept Prot Sci, Sch Engn Sci Chem Biotechnol & Hlth,Sci Life Lab, Stockholm, Sweden
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(creator_code:org_t)
- 2019-06-26
- 2019
- English.
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In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 9
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- There is a growing recognition of the importance of point-of-care tests (POCTs) for detecting critical neonatal illnesses to reduce the mortality rate in newborns, especially in low-income countries, which account for 98 percent of reported neonatal deaths. Lactate dehydrogenase (LDH) is a marker of cellular damage as a result of hypoxia-ischemia in affected organs. Here, we describe and test a POC LDH test direct from whole blood to provide early indication of serious illness in the neonate. The sample-inresult- out POC platform is specifically designed to meet the needs at resource-limited settings. Plasma is separated from whole blood on filter paper with dried-down reagents for colorimetric reaction, combined with software for analysis using a smartphone. The method was clinically tested in newborns in two different settings. In a clinical cohort of newborns of Stockholm (n = 62) and Hanoi (n = 26), the value of R using Pearson's correlation test was 0.91 (p < 0.01) and the R-2 = 0.83 between the two methods. The mean LDH (+/- SD) for the reference method vs. the POC-LDH was 551 (+/- 280) U/L and 552 (+/- 249) U/L respectively, indicating the clinical value of LDH values measured in minutes with the POC was comparable with standardized laboratory analyses.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Halvorsen, Cecil ...
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Olson, Linus
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Araujo, Ana Cata ...
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Karlsson, Mathia ...
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Nguyen, Trang Th ...
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Khu, Dung T. K.
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Le, Ha T. T.
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Nguyen, Hoa T. B ...
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Winbladh, Birger
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Russom, Aman, As ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
- Articles in the publication
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Scientific Repor ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet
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Uppsala University