Search: onr:"swepub:oai:DiVA.org:kth-262787" >
High-definition spa...
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Vickovic, SanjaKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
(author)
High-definition spatial transcriptomics for in situ tissue profiling
- Article/chapterEnglish2019
Publisher, publication year, extent ...
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2019-09-09
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NATURE PUBLISHING GROUP,2019
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:kth-262787
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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262787URI
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https://doi.org/10.1038/s41592-019-0548-yDOI
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https://lup.lub.lu.se/record/42603f54-fcc1-48db-ae97-a9b25a752a2bURI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141979495URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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QC 20191022
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Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcriptcoupled spatial barcodes at 2-mu m resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Eraslan, GokcenBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
(author)
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Salmén, FredrikKTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1bw72vj
(author)
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Klughammer, JohannaBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
(author)
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Stenbeck, LinneaKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1v835xb
(author)
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Schapiro, DenisBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;Harvard Med Sch, Lab Syst Pharmacol, Boston, MA 02115 USA.,Broad Institute,Harvard University
(author)
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Aijo, TarmoFlatiron Inst, Ctr Computat Biol, New York, NY USA.,Simons Foundation
(author)
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Bonneau, RichardNYU, Ctr Data Sci, New York, NY USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.,Brigham and Women's Hospital / Harvard Medical School,New York University
(author)
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Bergenstrahle, JosephKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1f4ltny
(author)
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Fernandez Navarro, JoseKTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u11gbovc
(author)
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Gould, JoshuaBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute
(author)
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Griffin, Gabriel K.Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.,Brigham and Women's Hospital / Harvard Medical School,Broad Institute
(author)
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Borg, ÅkeLund University,Lunds universitet,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Familial Breast Cancer,Lund University Research Groups(Swepub:lu)onk-abo
(author)
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Ronaghi, MostafaIllumina Inc, San Diego, CA USA.
(author)
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Frisen, JonasKarolinska Institutet,Karolinska Institute
(author)
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Lundeberg, JoakimKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.,Stanford University(Swepub:kth)u1qkn9kw
(author)
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Regev, AvivBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;MIT, Howard Hughes Med Inst, Cambridge, MA USA.;MIT, Dept Biol, Koch Inst Integrat Canc Res, Cambridge, MA USA.,Broad Institute,Massachusetts Institute of Technology
(author)
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Ståhl, Patrik,Dr.KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1rstx38
(author)
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Bergenstråhle, LudvigKTH Royal Institute of Technology
(author)
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KTHScience for Life Laboratory, SciLifeLab
(creator_code:org_t)
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In:Nature Methods: NATURE PUBLISHING GROUP16:10, s. 987-+1548-70911548-7105
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Vickovic, Sanja
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Eraslan, Gokcen
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Salmén, Fredrik
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Klughammer, Joha ...
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Stenbeck, Linnea
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Schapiro, Denis
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Aijo, Tarmo
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Bonneau, Richard
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Bergenstrahle, J ...
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Fernandez Navarr ...
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Gould, Joshua
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Griffin, Gabriel ...
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Borg, Åke
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Ronaghi, Mostafa
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Frisen, Jonas
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Lundeberg, Joaki ...
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Regev, Aviv
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Ståhl, Patrik, D ...
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Bergenstråhle, L ...
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