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  • Vickovic, SanjaKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute (author)

High-definition spatial transcriptomics for in situ tissue profiling

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2019-09-09
  • NATURE PUBLISHING GROUP,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-262787
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-262787URI
  • https://doi.org/10.1038/s41592-019-0548-yDOI
  • https://lup.lub.lu.se/record/42603f54-fcc1-48db-ae97-a9b25a752a2bURI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:141979495URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20191022
  • Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcriptcoupled spatial barcodes at 2-mu m resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues.

Subject headings and genre

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  • Eraslan, GokcenBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute (author)
  • Salmén, FredrikKTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1bw72vj (author)
  • Klughammer, JohannaBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute (author)
  • Stenbeck, LinneaKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1v835xb (author)
  • Schapiro, DenisBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;Harvard Med Sch, Lab Syst Pharmacol, Boston, MA 02115 USA.,Broad Institute,Harvard University (author)
  • Aijo, TarmoFlatiron Inst, Ctr Computat Biol, New York, NY USA.,Simons Foundation (author)
  • Bonneau, RichardNYU, Ctr Data Sci, New York, NY USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.,Brigham and Women's Hospital / Harvard Medical School,New York University (author)
  • Bergenstrahle, JosephKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u1f4ltny (author)
  • Fernandez Navarro, JoseKTH Royal Institute of Technology,KTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u11gbovc (author)
  • Gould, JoshuaBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.,Broad Institute (author)
  • Griffin, Gabriel K.Broad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA.,Brigham and Women's Hospital / Harvard Medical School,Broad Institute (author)
  • Borg, ÅkeLund University,Lunds universitet,Familjär bröstcancer,Forskargrupper vid Lunds universitet,Familial Breast Cancer,Lund University Research Groups(Swepub:lu)onk-abo (author)
  • Ronaghi, MostafaIllumina Inc, San Diego, CA USA. (author)
  • Frisen, JonasKarolinska Institutet,Karolinska Institute (author)
  • Lundeberg, JoakimKTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA.,Stanford University(Swepub:kth)u1qkn9kw (author)
  • Regev, AvivBroad Inst MIT & Harvard, Klarman Cell Observ, Cambridge, MA 02142 USA.;MIT, Howard Hughes Med Inst, Cambridge, MA USA.;MIT, Dept Biol, Koch Inst Integrat Canc Res, Cambridge, MA USA.,Broad Institute,Massachusetts Institute of Technology (author)
  • Ståhl, Patrik,Dr.KTH Royal Institute of Technology,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1rstx38 (author)
  • Bergenstråhle, LudvigKTH Royal Institute of Technology (author)
  • KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)

Related titles

  • In:Nature Methods: NATURE PUBLISHING GROUP16:10, s. 987-+1548-70911548-7105

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