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  • Gharpure, AnantUniv Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA. (author)

Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • CELL PRESS,2019
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-264322
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-264322URI
  • https://doi.org/10.1016/j.neuron.2019.07.030DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-176555URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20191202
  • Nicotinic acetylcholine receptors are pentameric ion channels that mediate fast chemical neurotransmission. The alpha 3 beta 4 nicotinic receptor subtype forms the principal relay between the central and peripheral nervous systems in the autonomic ganglia. This receptor is also expressed focally in brain areas that affect reward circuits and addiction. Here, we present structures of the alpha 3 beta 4 nicotinic receptor in lipidic and detergent environments, using functional reconstitution to define lipids appropriate for structural analysis. The structures of the receptor in complex with nicotine, as well as the alpha 3 beta 4-selective ligand AT-1001, complemented by molecular dynamics, suggest principles of agonist selectivity. The structures further reveal much of the architecture of the intracellular domain, where mutagenesis experiments and simulations define residues governing ion conductance.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Teng, JinfengUniv Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA. (author)
  • Zhuang, YuxuanStockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)yuzh9105 (author)
  • Noviello, Colleen M.Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA. (author)
  • Walsh, Richard M., Jr.Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA.;Harvard Med Sch, Dept Biol Chem & Mol Pharmacol, Boston, MA 02115 USA. (author)
  • Cabuco, RicoUniv Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA. (author)
  • Howard, Rebecca J.Stockholms universitet,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab)(Swepub:su)rhowa (author)
  • Zaveri, Nurulain T.Astraea Therapeut, Mountain View, CA 94043 USA. (author)
  • Lindahl, Erik,1972-Stockholms universitet,KTH,SeRC - Swedish e-Science Research Centre,Tillämpad fysik,Institutionen för biokemi och biofysik,Science for Life Laboratory (SciLifeLab),KTH Royal Institute of Technology, Sweden(Swepub:su)erlin (author)
  • Hibbs, Ryan E.Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA. (author)
  • Univ Texas Southwestern Med Ctr Dallas, Dept Neurosci, Dallas, TX 75390 USA.Institutionen för biokemi och biofysik (creator_code:org_t)

Related titles

  • In:Neuron: CELL PRESS104:3, s. 501-+0896-62731097-4199

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