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Replication-biased genome organisation in the crenarchaeon Sulfolobus
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- Andersson, Anders (author)
- Uppsala universitet,KTH,Science for Life Laboratory, SciLifeLab,Genteknologi,Institutionen för ekologi och evolution,Limnologi,Molekylär evolution
- Pelve, Erik A. (author)
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- Lindeberg, Stefan (author)
- Uppsala universitet,Molekylär evolution
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- (creator_code:org_t)
- Springer Science and Business Media LLC, 2010
- 2010
- English.
- In: BMC Genomics. - : Springer Science and Business Media LLC. - 1471-2164. ; 11, s. 454-
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Background: Species of the crenarchaeon Sulfolobus harbour three replication origins in their single circular chromosome that are synchronously initiated during replication. Results: We demonstrate that global gene expression in two Sulfolobus species is highly biased, such that early replicating genome regions are more highly expressed at all three origins. The bias by far exceeds what would be anticipated by gene dosage effects alone. In addition, early replicating regions are denser in archaeal core genes (enriched in essential functions), display lower intergenic distances, and are devoid of mobile genetic elements. Conclusion: The strong replication-biased structuring of the Sulfolobus chromosome implies that the multiple replication origins serve purposes other than simply shortening the time required for replication. The higher-level chromosomal organisation could be of importance for minimizing the impact of DNA damage, and may also be linked to transcriptional regulation.
Subject headings
- TEKNIK OCH TEKNOLOGIER -- Industriell bioteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Industrial Biotechnology (hsv//eng)
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
Keyword
- CELL-CYCLE CHARACTERISTICS
- ARCHAEON SULFOLOBUS
- GENE-EXPRESSION
- THERMOPHILIC ARCHAEA
- CHROMATIN PROTEIN
- ESCHERICHIA-COLI
- SOLFATARICUS
- BACTERIA
- TRANSCRIPTION
- EUKARYOTES
- Bioengineering
- Bioteknik
- Biology
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- BMC Genomics
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- Royal Institute of Technology
- Uppsala University
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