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Investigation of the Factors That Dictate the Preferred Orientation of Lexitropsins in the Minor Groove of DNA
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- Alniss, Hasan Y. (author)
- Univ Sharjah, Coll Pharm, POB 27272, Sharjah, U Arab Emirates.;Univ Sharjah, Sharjah Inst Med Res, POB 27272, Sharjah, U Arab Emirates.
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- Witzel, Ini-Isabee (author)
- New York Univ Abu Dhabi, Core Technol Platform, POB 129188, Abu Dhabi, U Arab Emirates.
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- Semreen, Mohammad H. (author)
- Univ Sharjah, Coll Pharm, POB 27272, Sharjah, U Arab Emirates.;Univ Sharjah, Sharjah Inst Med Res, POB 27272, Sharjah, U Arab Emirates.
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- Univ Sharjah, Coll Pharm, POB 27272, Sharjah, U Arab Emirates;Univ Sharjah, Sharjah Inst Med Res, POB 27272, Sharjah, U Arab Emirates. New York Univ Abu Dhabi, Core Technol Platform, POB 129188, Abu Dhabi, U Arab Emirates. (creator_code:org_t)
- 2019-10-28
- 2019
- English.
- In: Journal of Medicinal Chemistry. - : AMER CHEMICAL SOC. - 0022-2623 .- 1520-4804. ; 62:22, s. 10423-10440
- Journal article (peer-reviewed)
Abstract
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- Lexitropsins are small molecules that bind to the minor groove of DNA as antiparallel dimers in a specific orientation. These molecules have shown therapeutic potential in the treatment of several diseases; however, the development of these molecules to target particular genes requires revealing the factors that dictate their preferred orientation in the minor grooves, which to date have not been investigated. In this study, a distinct structure (thzC) was carefully designed as an analog of a well-characterized lexitropsin (thzA) to reveal the factors that dictate the preferred binding orientation. Comparative evaluations of the biophysical and molecular modeling results of both compounds showed that the position of the dimethylaminopropyl group and the orientation of the amide links of the ligand with respect to the 5'-3'-ends; dictate the preferred orientation of lexitropsins in the minor grooves. These findings could be useful in the design of novel lexitropsins to selectively target specific genes.
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Läkemedelskemi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medicinal Chemistry (hsv//eng)
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