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High-dimensional multi-block analysis of factors associated with thrombin generation potential
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- Lorenzo, Hadrien (author)
- Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, SISTM Team, Inria BSO,Inserm,U1219, Bordeaux, France.
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- Razzaq, Misbah (author)
- Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, VINTAGE Team, Inserm,U1219, Bordeaux, France.
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- Odeberg, Jacob, Professor, 1963- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
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- Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, SISTM Team, Inria BSO,Inserm,U1219, Bordeaux, France Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, VINTAGE Team, Inserm,U1219, Bordeaux, France. (creator_code:org_t)
- IEEE, 2019
- 2019
- English.
- In: Proceedings 2019 IEEE 32ND INTERNATIONAL SYMPOSIUM ON COMPUTER-BASED MEDICAL SYSTEMS (CBMS). - : IEEE. - 9781728122861 - 9781728122878 ; , s. 453-458
- Conference paper (peer-reviewed)
Abstract
Subject headings
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- The identification of novel biological factors associated with thrombin generation, a key biomarker of the coagulation process, remains a relevant strategy to disentangle pathophysiological mechanisms underlying the risk of venous thrombosis (VT). As part of the MARseille THrombosis Association Study (MARTHA), we measured whole blood DNA methylation levels, plasma levels of 300 proteins, 3 thrombin generation biomarkers (endogeneous thrombin potential, peak and lagtime), clinical and genetic data in 700 patients with VT. The application of a novel high-dimensional multi-levels statistical methodology we recently developed, the data driven sparse Partial Least Square method (ddsPLS), on the MARTHA datasets enabled us 1/ to confirm the role of a known mutation of the variability of endogenous thrombin potential and peak, 2/ to identify a new signature of 7 proteins strongly associated with lagtime.
Subject headings
- NATURVETENSKAP -- Data- och informationsvetenskap (hsv//swe)
- NATURAL SCIENCES -- Computer and Information Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- Multi-Omics
- High Dimensional Data
- Missing Data
- SVD
- Partial Least Square
- Variable Selection
- Multi-Block Analysis
- Machine Learning
- Thrombine Generation
Publication and Content Type
- ref (subject category)
- kon (subject category)
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