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A genome-wide transcriptomic analysis of protein-coding genes in human blood cells

Uhlén, Mathias (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden;Karolinska Inst, Dept Neurosci, Stockholm, Sweden;Tech Univ Denmark, Novo Nordisk Fdn Ctr Biosustainabil, Lyngby, Denmark
Karlsson, Max (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Zhong, Wen (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
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Abdellah, Tebani (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Pou, Christian (author)
Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden.
Mikes, Jaromir (author)
Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden
Lakshmikanth, Tadepally (author)
Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden
Forsström, Björn (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Edfors, Fredrik (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Odeberg, Jacob, Professor, 1963- (author)
Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden;Karolinska Univ Hosp, Coagulat Unit, Dept Hematol, Stockholm, Sweden
Mardinoglu, Adil (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden;Kings Coll London, Ctr Host Microbiome Interact, Fac Dent Oral & Craniofacial Sci, London, England
Zhang, Cheng (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
von Feilitzen, Kalle (author)
KTH,Systembiologi,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Mulder, Jan (author)
Karolinska Institutet,Karolinska Inst, Dept Neurosci, Stockholm, Sweden
Sjostedt, Evelina (author)
Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
Hober, Andreas (author)
KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Oksvold, Per (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Zwahlen, Martin (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Pontén, Fredrik (author)
Uppsala universitet,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden.,Uppsala universitet, Klinisk och experimentell patologi, Sweden
Lindskog, Cecilia (author)
Uppsala universitet,Klinisk och experimentell patologi,Uppsala Univ, Dept Immunol Genet & Pathol, Rudbeck Lab, Uppsala, Sweden.,Uppsala universitet, Klinisk och experimentell patologi, Sweden
Sivertsson, Åsa (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Fagerberg, Linn (author)
KTH,Science for Life Laboratory, SciLifeLab,KTH Royal Inst Technol, Sci Life Lab, Stockholm, Sweden
Brodin, Petter (author)
Karolinska Institutet,Karolinska Inst, Dept Womens & Childrens Hlth, Sci Life Lab, Stockholm, Sweden;Karolinska Univ Hosp, Unit Pediat Rheumatol, Stockholm, Sweden
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 (creator_code:org_t)
American Association for the Advancement of Science, 2019
2019
English.
In: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 366:6472, s. 1471-
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Blood is the predominant source for molecular analyses in humans, both in clinical and research settings. It is the target for many therapeutic strategies, emphasizing the need for comprehensive molecular maps of the cells constituting human blood. In this study, we performed a genome-wide transcriptomic analysis of protein-coding genes in sorted blood immune cell populations to characterize the expression levels of each individual gene across the blood cell types. All data are presented in an interactive, open-access Blood Atlas as part of the Human Protein Atlas and are integrated with expression profiles across all major tissues to provide spatial classification of all protein-coding genes. This allows for a genome-wide exploration of the expression profiles across human immune cell populations and all major human tissues and organs.

Subject headings

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)

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