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Poly(epsilon-caprol...
Poly(epsilon-caprolactone-co-p-dioxanone) : a Degradable and Printable Copolymer for Pliable 3D Scaffolds Fabrication toward Adipose Tissue Regeneration
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- Fuoco, Tiziana, PhD, 1986- (author)
- KTH,Fiber- och polymerteknologi
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- Ahlinder, Astrid (author)
- KTH,Fiberteknologi
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- Jain, Shubham (author)
- KTH,Fiber- och polymerteknologi
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- Mustafa, Kamal (author)
- Univ Bergen, Fac Med, Dept Clin Dent, N-5020 Bergen, Norway.
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- Finne Wistrand, Anna, 1976- (author)
- KTH,Polymerteknologi
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(creator_code:org_t)
- 2019-09-24
- 2020
- English.
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In: Biomacromolecules. - : AMER CHEMICAL SOC. - 1525-7797 .- 1526-4602. ; 21:1, s. 188-198
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The advancement of 3D printing technologies in the fabrication of degradable scaffolds for tissue engineering includes, from the standpoint of the polymer chemists, an urgent need to develop new materials that can be used as ink and are suitable for medical applications. Here, we demonstrate that a copolymer of epsilon-caprolactone (CL) with low amounts of p-dioxanone (DX) (15 mol %) is a degradable and printable material that suits the requirements of melt extrusion 3D printing technologies, including negligible degradation during thermal processing. It is therefore a potential candidate for soft tissue regeneration. The semicrystalline CL/DX copolymer is processed at a lower temperature than a commercial polycaprolactone (PCL), shaped as a filament for melt extrusion 3D printing and as porous and pliable scaffolds with a gradient design. Scaffolds have Young's modulus in the range of 60-80 MPa, values suitable for provision of structural support for damaged soft tissue such as breast tissue. SEM and confocal microscope indicate that the CL/DX copolymer scaffolds support adipose stem cell attachment, spreading, and proliferation.
Subject headings
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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