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- Sungnak, W. (author)
SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes
- Article/chapterEnglish2020
Publisher, publication year, extent ...
- 2020-04-23
- Nature Research,2020
- printrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:kth-273986
- https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-273986URI
- https://doi.org/10.1038/s41591-020-0868-6DOI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- QC 20200625
- We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-associated genes in single-cell RNA-sequencing data from multiple tissues from healthy human donors. We co-detected these transcripts in specific respiratory, corneal and intestinal epithelial cells, potentially explaining the high efficiency of SARS-CoV-2 transmission. These genes are co-expressed in nasal epithelial cells with genes involved in innate immunity, highlighting the cells’ potential role in initial viral infection, spread and clearance. The study offers a useful resource for further lines of inquiry with valuable clinical samples from COVID-19 patients and we provide our data in a comprehensive, open and user-friendly fashion at www.covid19cellatlas.org.
Subject headings and genre
- angiotensin converting enzyme 2
- atp10b protein
- c15orf48 protein
- cathepsin B
- cathepsin L
- cdc42ep5 protein
- crym protein
- cyp2f1 protein
- duoxa2 protein
- fam3d protein
- fcgbp protein
- ido1 protein
- lypd2 protein
- messenger RNA
- mx1 protein
- oas1 protein
- prkar2b protein
- prostate stem cell antigen
- protein
- protein S 100
- proteinase
- rarres1 protein
- slc5a8 protein
- spdef protein
- st3gal4 enzyme
- st6gal1 enzyme
- tmprss2 protein
- ube2l6 protein
- unclassified drug
- virus enzyme
- vitronectin
- Article
- colon tissue
- comparative study
- cornea epithelium
- cornea tissue
- coronavirus disease 2019
- epithelium cell
- esophagus tissue
- fetus
- fetus tissue
- gene expression
- gene expression level
- heart tissue
- human
- human cell
- human tissue
- ileum tissue
- immune response gene
- innate immunity
- kidney tissue
- liver tissue
- marker gene
- muscle tissue
- nose epithelium
- pancreas tissue
- priority journal
- prostate tissue
- retina tissue
- Severe acute respiratory syndrome coronavirus 2
- single cell RNA seq
- skeletal muscle
- spleen tissue
- testis tissue
- viral tropism
- virus entry
- virus transmission
Added entries (persons, corporate bodies, meetings, titles ...)
- Huang, N. (author)
- Bécavin, C. (author)
- Berg, M. (author)
- Queen, R. (author)
- Litvinukova, M. (author)
- Talavera-López, C. (author)
- Maatz, H. (author)
- Reichart, D. (author)
- Sampaziotis, F. (author)
- Worlock, K. B. (author)
- Yoshida, M. (author)
- Barnes, J. L. (author)
- Banovich, N. E. (author)
- Barbry, P. (author)
- Brazma, A. (author)
- Collin, J. (author)
- Desai, T. J. (author)
- Duong, T. E. (author)
- Eickelberg, O. (author)
- Falk, C. (author)
- Farzan, M. (author)
- Glass, I. (author)
- Gupta, R. K. (author)
- Haniffa, M. (author)
- Horvath, P. (author)
- Hubner, N. (author)
- Hung, D. (author)
- Kaminski, N. (author)
- Krasnow, M. (author)
- Kropski, J. A. (author)
- Kuhnemund, M. (author)
- Lako, M. (author)
- Lee, H. (author)
- Leroy, S. (author)
- Linnarson, S. (author)
- Lundeberg, JoakimKTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1qkn9kw (author)
- Meyer, K. B. (author)
- Miao, Z. (author)
- Misharin, A. V. (author)
- Nawijn, M. C. (author)
- Nikolic, M. Z. (author)
- Noseda, M. (author)
- Ordovas-Montanes, J. (author)
- Oudit, G. Y. (author)
- Pe’er, D. (author)
- Powell, J. (author)
- Quake, S. (author)
- Rajagopal, J. (author)
- Tata, P. R. (author)
- Rawlins, E. L. (author)
- Regev, A. (author)
- Reyfman, P. A. (author)
- Rozenblatt-Rosen, O. (author)
- Saeb-Parsy, K. (author)
- Samakovlis, ChristosKTH(Swepub:kth)PI000000 (author)
- Schiller, H. B. (author)
- Schultze, J. L. (author)
- Seibold, M. A. (author)
- Seidman, C. E. (author)
- Seidman, J. G. (author)
- Shalek, A. K. (author)
- Shepherd, D. (author)
- Spence, J. (author)
- Spira, A. (author)
- Sun, X. (author)
- Teichmann, S. A. (author)
- Theis, F. J. (author)
- Tsankov, A. M. (author)
- Vallier, L. (author)
- van den Berge, M. (author)
- Whitsett, J. (author)
- Xavier, R. (author)
- Xu, Y. (author)
- Zaragosi, L. -E (author)
- Zerti, D. (author)
- Zhang, H. (author)
- Zhang, K. (author)
- Rojas, M. (author)
- Figueiredo, F. (author)
- Network, HCA Lung Biological (author)
- KTHScience for Life Laboratory, SciLifeLab (creator_code:org_t)
Related titles
- In:Nature Medicine: Nature Research26:5, s. 681-6871078-89561546-170X
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- Brazma, A.
- Collin, J.
- Desai, T. J.
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