An Ultraminiaturized MEMS Microbiopsy Tool for Trans Blood Vessel Wall Biopsies

• We present a new type of microbiopsy tool (MBT) an order of magnitude smaller than commercially available biopsy catheters that, together with a trans-vessel wall catheter (Extroducer) successfully samples soft tissues with significantly less trauma to the tissue than commercial catheters. The MBT is mounted on a Nitinol wire. It features a gripping action that is actuated by the relative motion inside the Extroducer and has demonstrated repeated successful tissue sampling of approximately 500-1000 cells in ex-vivo tissue. This new catheter system can potentially allow super-selective, minimally invasive tissue sampling and transcriptomic analysis from hard to reach areas. 

Subject headings

TEKNIK OCH TEKNOLOGIER  -- Medicinteknik -- Medicinsk apparatteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Medical Engineering -- Medical Equipment Engineering (hsv//eng)

Keyword

Biopsy

catheter

MEMS

minimally invasive

Blood vessels

Catheters

Mechanics

Tissue

Blood vessel walls

Microbiopsy tool

Nitinol wires

Relative motion

Soft tissue

Tissue sampling

Vessel walls

Publication and Content Type

ref (subject category)

kon (subject category)