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Molecular atlas of ...
Molecular atlas of the adult mouse brain
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- Ortiz, Cantin (author)
- Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
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- Fernandez Navarro, Jose (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Jurek, Aleksandra (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab
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- Martin, Antje (author)
- Karolinska Inst, Dept Neurosci, Stockholm, Sweden.
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- Lundeberg, Joakim (author)
- KTH,Science for Life Laboratory, SciLifeLab,Genteknologi
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- Meletis, Konstantinos (author)
- Karolinska Institutet
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Karolinska Inst, Dept Neurosci, Stockholm, Sweden Genteknologi (creator_code:org_t)
- American Association for the Advancement of Science (AAAS), 2020
- 2020
- English.
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In: Science Advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 6:26
- Related links:
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https://doi.org/10.1...
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https://www.science....
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Brain maps are essential for integrating information and interpreting the structure-function relationship of circuits and behavior. We aimed to generate a systematic classification of the adult mouse brain based purely on the unbiased identification of spatially defining features by employing whole-brain spatial transcriptomics. We found that the molecular information was sufficient to deduce the complex and detailed neuroanatomical organization of the brain. The unsupervised (non-expert, data-driven) classification revealed new area- and layer-specific subregions, for example in isocortex and hippocampus, and new subdivisions of striatum. The molecular atlas further supports the characterization of the spatial identity of neurons from their single-cell RNA profile, and provides a resource for annotating the brain using a minimal gene set-a brain palette. In summary, we have established a molecular atlas to formally define the spatial organization of brain regions, including the molecular code for mapping and targeting of discrete neuroanatomical domains.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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