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Profiles of histidi...
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality
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- Hong, Mun-Gwan (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Dodig-Crnkovic, Tea (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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Chen, Xu (author)
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- Drobin, Kimi (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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Lee, Woojoo (author)
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- Wang, Yunzhang (author)
- Karolinska Institutet
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- Edfors, Fredrik (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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Kotol, David (author)
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- Thomas, Cecilia Engel (author)
- KTH,Affinitets-proteomik,Science for Life Laboratory, SciLifeLab
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Sjöberg, Ronald (author)
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- Odeberg, Jacob, Professor, 1963- (author)
- Karolinska Institutet,KTH,Science for Life Laboratory, SciLifeLab,Cellulär och klinisk proteomik
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- Hamsten, Anders (author)
- Karolinska Institutet
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- Silveira, Angela (author)
- Karolinska Institutet
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- Hall, Per (author)
- Karolinska Institutet
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- Nilsson, Peter (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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- Pawitan, Yudi (author)
- Karolinska Institutet
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- Uhlén, Mathias (author)
- KTH,Science for Life Laboratory, SciLifeLab,Systembiologi
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- Pedersen, Nancy L (author)
- Karolinska Institutet
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- Hägg, Sara (author)
- Karolinska Institutet
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- Magnusson, Patrik KE (author)
- Karolinska Institutet
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- Schwenk, Jochen M. (author)
- KTH,Science for Life Laboratory, SciLifeLab,Affinitets-proteomik
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(creator_code:org_t)
- 2020-07-31
- 2020
- English.
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In: Life Science Alliance. - : Life Science Alliance, LLC. - 2575-1077. ; 3:10, s. e202000817-
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https://doi.org/10.2...
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https://www.life-sci...
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Abstract
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- Despite recognizing aging as a common risk factor of many human diseases, little is known about its molecular traits. To identify age-associated proteins circulating in human blood, we screened 156 individuals aged 50–92 using exploratory and multiplexed affinity proteomics assays. Profiling eight additional study sets (N = 3,987), performing antibody validation, and conducting a meta-analysis revealed a consistent age association (P = 6.61 × 10−6) for circulating histidine-rich glycoprotein (HRG). Sequence variants of HRG influenced how the protein was recognized in the immunoassays. Indeed, only the HRG profiles affected by rs9898 were associated with age and predicted the risk of mortality (HR = 1.25 per SD; 95% CI = 1.12–1.39; P = 6.45 × 10−5) during a follow-up period of 8.5 yr after blood sampling (IQR = 7.7–9.3 yr). Our affinity proteomics analysis found associations between the particular molecular traits of circulating HRG with age and all-cause mortality. The distinct profiles of this multipurpose protein could serve as an accessible and informative indicator of the physiological processes related to biological aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Hong, Mun-Gwan
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Dodig-Crnkovic, ...
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Chen, Xu
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Drobin, Kimi
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Lee, Woojoo
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Wang, Yunzhang
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show more...
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Edfors, Fredrik
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Kotol, David
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Thomas, Cecilia ...
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Sjöberg, Ronald
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Odeberg, Jacob, ...
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Hamsten, Anders
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Silveira, Angela
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Hall, Per
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Nilsson, Peter
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Pawitan, Yudi
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Uhlén, Mathias
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Pedersen, Nancy ...
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Hägg, Sara
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Magnusson, Patri ...
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Schwenk, Jochen ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Medical Biotechn ...
- Articles in the publication
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Life Science All ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet