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Nitric oxide-depend...
Nitric oxide-dependent biodegradation of graphene oxide reduces inflammation in the gastrointestinal tract
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- Peng, Guotao (author)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
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- Montenegro, Marcelo F. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.
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- Ntola, Chifundo N. M. (author)
- Univ Manchester, Natl Graphene Inst, Manchester, Lancs, England.;Univ Manchester, Fac Biol, Manchester, Lancs, England.
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- Vranic, Sandra (author)
- Univ Manchester, Natl Graphene Inst, Manchester, Lancs, England.;Univ Manchester, Fac Biol, Manchester, Lancs, England.
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- Kostarelos, Kostas (author)
- Univ Manchester, Natl Graphene Inst, Manchester, Lancs, England.;Univ Manchester, Fac Biol, Manchester, Lancs, England.;Catalan Inst Nanosci & Nanotechnol ICN2, Barcelona, Spain.
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- Vogt, Carmen (author)
- KTH,Biomedicinsk fysik och röntgenfysik,Albanova VinnExcellence Center for Protein Technology, ProNova,KTH Royal Inst Technol, Dept Appl Phys, Stockholm, Sweden.
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- Toprak, Muhammet S. (author)
- KTH,Dept Appl Phys, Stockholm, Sweden.,KTH Royal Inst Technol, Dept Appl Phys, Stockholm, Sweden.
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- Duan, Tianbo (author)
- Uppsala universitet,Tillämpad materialvetenskap
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- Leifer, Klaus, 1965- (author)
- Uppsala universitet,Tillämpad materialvetenskap
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- Brautigam, Lars (author)
- Karolinska Institutet
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- Lundberg, Jon O. (author)
- Karolinska Institutet
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- Fadeel, Bengt (author)
- Karolinska Institutet
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Karolinska Inst, Inst Environm Med, Stockholm, Sweden Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden. (creator_code:org_t)
- 2020
- 2020
- English.
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In: Nanoscale. - : Royal Society of Chemistry (RSC). - 2040-3364 .- 2040-3372. ; 12:32, s. 16730-16737
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Abstract
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- Understanding the biological fate of graphene-based materials such as graphene oxide (GO) is crucial to assess adverse effects following intentional or inadvertent exposure. Here we provide first evidence of biodegradation of GO in the gastrointestinal tract using zebrafish as a model. Raman mapping was deployed to assess biodegradation. The degradation was blocked upon knockdown ofnos2aencoding the inducible nitric oxide synthase (iNOS) or by pharmacological inhibition of NOS usingl-NAME, demonstrating that the process was nitric oxide (NO)-dependent. NO-dependent degradation of GO was further confirmedin vitroby combining a superoxide-generating system, xanthine/xanthine oxidase (X/XO), with an NO donor (PAPA NONOate), or by simultaneously producing superoxide and NO by decomposition of SIN-1. Finally, by using the transgenic strainTg(mpx:eGFP) to visualize the movement of neutrophils, we could show that inhibition of the degradation of GO resulted in increased neutrophil infiltration into the gastrointestinal tract, indicative of inflammation.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
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- ref (subject category)
- art (subject category)
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Nanoscale
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- By the author/editor
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Peng, Guotao
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Montenegro, Marc ...
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Ntola, Chifundo ...
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Vranic, Sandra
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Kostarelos, Kost ...
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Vogt, Carmen
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Toprak, Muhammet ...
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Duan, Tianbo
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Leifer, Klaus, 1 ...
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Brautigam, Lars
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Lundberg, Jon O.
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Fadeel, Bengt
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Chemical Science ...
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and Materials Chemis ...
- Articles in the publication
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Nanoscale
- By the university
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Royal Institute of Technology
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Uppsala University
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Karolinska Institutet