Search: onr:"swepub:oai:DiVA.org:kth-281143" > Spatial Transcripto...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 06523naa a2200565 4500 | |
001 | oai:DiVA.org:kth-281143 | |
003 | SwePub | |
008 | 201007s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-2811432 URI |
024 | 7 | a https://doi.org/10.1016/j.cell.2020.06.0382 DOI |
040 | a (SwePub)kth | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Chen, Wei-Tingu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
245 | 1 0 | a Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease |
264 | 1 | b Elsevier BV,c 2020 |
338 | a print2 rdacarrier | |
500 | a QC 20201007 | |
520 | a Although complex inflammatory-like alterations are observed around the amyloid plaques of Alzheimer's disease (AD), little is known about the molecular changes and cellular interactions that characterize this response, We investigate here, in an AD mouse model, the transcriptional changes occurring in tissue domains in a 100-mu m diameter around amyloid plaques using spatial transcriptomics. We demonstrate early alterations in a gene co-expression network enriched for myelin and oligodendrocyte genes (OLIGs), whereas a multicellular gene co-expression network of plaque-induced genes (PIGs) involving the complement system, oxidative stress, lysosomes, and inflammation is prominent in the later phase of the disease. We confirm the majority of the observed alterations at the cellular level using in situ sequencing on mouse and human brain sections. Genome-wide spatial transcriptomics analysis provides an unprecedented approach to untangle the dysregulated cellular network in the vicinity of pathogenic hallmarks of AD and other brain diseases. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
700 | 1 | a Lu, Ashleyu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Craessaerts, Katleenu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Pavie, Benjaminu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Frigerio, Carlo Salau VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England.4 aut |
700 | 1 | a Corthout, Nikkyu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Qian, Xiaoyanu Cartana AB, Nobels Vag 16, S-17165 Solna, Sweden.4 aut |
700 | 1 | a Lalakova, Janau Cartana AB, Nobels Vag 16, S-17165 Solna, Sweden.4 aut |
700 | 1 | a Kuhnemund, Malteu Cartana AB, Nobels Vag 16, S-17165 Solna, Sweden.4 aut |
700 | 1 | a Voytyuk, Irynau VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Wolfs, Leenu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Mancuso, Renzou VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Salta, Evgeniau VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Balusu, Sriramu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Snellinx, Anu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Munck, Sebastianu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 aut |
700 | 1 | a Jurek, Aleksandrau KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u1qtfp9v |
700 | 1 | a Fernandez Navarro, Joseu KTH,Genteknologi,Science for Life Laboratory, SciLifeLab4 aut0 (Swepub:kth)u11gbovc |
700 | 1 | a Saido, Takaomi C.u RIKEN Brain Sci Inst, Lab Proteolyt Neurosci, Wako, Saitama 3510198, Japan.4 aut |
700 | 1 | a Huitinga, Ingeu Royal Netherlands Acad Arts & Sci, Netherlands Inst Neurosci, Dept Neuroimmunol, NL-1105 BA Amsterdam, Netherlands.;Univ Amsterdam, Swammerdam Inst Life Sci, NL-1098 XH Amsterdam, Netherlands.4 aut |
700 | 1 | a Lundeberg, Joakimu KTH,Science for Life Laboratory, SciLifeLab,Genteknologi4 aut0 (Swepub:kth)u1qkn9kw |
700 | 1 | a Fiers, Marku VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England.4 aut |
700 | 1 | a De Strooper, Bartu VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;UCL, UK Dementia Res Inst, London WC1E 6BT, England.4 aut |
710 | 2 | a VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.b VIB Ctr Brain & Dis Res, B-3000 Leuven, Belgium.;Katholieke Univ Leuven, Dept Neurosci, Leuven Brain Inst, B-3000 Leuven, Belgium.;VIB Bio Imaging Core, B-9052 Ghent, Belgium.;VIB Bio Imaging Core, B-3000 Leuven, Belgium.4 org |
773 | 0 | t Celld : Elsevier BVg 182:4, s. 976-+q 182:4<976-+x 0092-8674x 1097-4172 |
856 | 4 | u http://www.cell.com/article/S0092867420308151/pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-281143 |
856 | 4 8 | u https://doi.org/10.1016/j.cell.2020.06.038 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Copy and save the link in order to return to this view