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Model-Informed Prec...
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy
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- Darwich, Adam S. (author)
- KTH,Hälsoinformatik och logistik
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Polasek, Thomas M. (author)
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Aronson, Jeffrey K. (author)
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Ogungbenro, Kayode (author)
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Wright, Daniel F.B. (author)
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Achour, Brahim (author)
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Reny, Jean-Luc (author)
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Daali, Youssef (author)
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- Eiermann, Birgit (author)
- Karolinska Institutet
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Cook, Jack (author)
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Lesko, Lawrence (author)
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McLachlan, Andrew J. (author)
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Rostami-Hodjegan, Amin (author)
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Insel, PA (author)
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(creator_code:org_t)
- Annual Reviews Inc. 2021
- 2021
- English.
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In: Annual Review of Pharmacology and Toxicology. - : Annual Reviews Inc.. - 0362-1642 .- 1545-4304. ; 61:36, s. 1-21
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https://kth.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Model-informed precision dosing (MIPD) has become synonymous with modern approaches forindividualizing drug therapy, in which the characteristics of each patient are considered as opposedto applying a one-size-fits-all alternative. This review provides a brief account of the currentknowledge, practices, and opinions on MIPD while defining an achievable vision for MIPDin clinical care based on available evidence.We begin with a historical perspective on variabilityin dose requirements and then discuss technical aspects of MIPD, including the need for clinicaldecision support tools, practical validation, and implementation of MIPD in health care.Wealso discuss novel ways to characterize patient variability beyond the common perceptions of geneticcontrol. Finally, we address current debates on MIPD from the perspectives of the new drugdevelopment, health-care economics, and drug regulations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Health Care Service and Management, Health Policy and Services and Health Economy (hsv//eng)
Keyword
- model-informed precision dosing
- MIPD
- individualized dosing
- pharmacokinetic/ pharmacodynamic modeling
- systems pharmacology
- clinical decision support systems
- electronic health records
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Darwich, Adam S.
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Polasek, Thomas ...
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Aronson, Jeffrey ...
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Ogungbenro, Kayo ...
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Wright, Daniel F ...
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Achour, Brahim
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show more...
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Reny, Jean-Luc
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Daali, Youssef
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Eiermann, Birgit
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Cook, Jack
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Lesko, Lawrence
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McLachlan, Andre ...
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Rostami-Hodjegan ...
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Insel, PA
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Health Care Serv ...
- Articles in the publication
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Annual Review of ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet