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Cerebrospinal Fluid...
Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson’s Disease
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- Markaki, I. (author)
- Karolinska Institutet
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- Bergström, Sofia (author)
- KTH,Affinitets-proteomik
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- Tsitsi, P. (author)
- Karolinska Institutet
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- Remnestål, Julia (author)
- KTH,Affinitets-proteomik
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- Månberg, Anna, 1985- (author)
- KTH,Affinitets-proteomik
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Hertz, E. (author)
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- Paslawski, W. (author)
- Karolinska Institutet
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- Sorjonen, K. (author)
- Karolinska Institutet
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- Uhlén, Mathias (author)
- Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
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Mangone, G. (author)
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Carvalho, S. (author)
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Rascol, O. (author)
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Meissner, W. G. (author)
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Magnin, E. (author)
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Wüllner, U. (author)
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Corvol, J. -C (author)
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- Nilsson, Peter (author)
- KTH,Affinitets-proteomik
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- Svenningsson, P. (author)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-08-15
- 2020
- English.
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In: Movement Disorders. - : John Wiley & Sons. - 0885-3185 .- 1531-8257.
- Related links:
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https://doi.org/10.1...
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https://movementdiso...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Background: Cognitive impairment is common in patients with PD. Core markers of Alzheimer’s dementia have been related also to PD dementia, but no disease-specific signature to predict PD dementia exists to date. Objectives: The aim of this study was to investigate CSF markers associated with cognition in early PD. Methods: A high-throughput suspension bead array examined 216 proteins in CSF of 74 PD patients in the AETIONOMY project. Cognitive function was assessed with Repeatable Battery for the Assessment of the Neuropsychological Status, Montreal Cognitive Assessment, and Mini-Mental State Examination. Results: Of 69 patients with complete data, 34 had high (≥90) and 35 had low Repeatable Battery for the Assessment of the Neuropsychological Status total score (<90). Of 14 proteins in CSF that differed in levels between groups, increased kininogen-1, validated with several antibodies, was independently associated with lower Repeatable Battery for the Assessment of the Neuropsychological Status and Montreal Cognitive Assessment scores after adjustment for confounders. Conclusions: Kininogen-1 levels in CSF may serve as a marker of cognitive impairment in PD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- cognition
- kininogen-1
- neurodegeneration
- Parkinson’s disease
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Markaki, I.
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Bergström, Sofia
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Tsitsi, P.
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Remnestål, Julia
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Månberg, Anna, 1 ...
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Hertz, E.
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show more...
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Paslawski, W.
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Sorjonen, K.
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Uhlén, Mathias
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Mangone, G.
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Carvalho, S.
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Rascol, O.
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Meissner, W. G.
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Magnin, E.
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Wüllner, U.
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Corvol, J. -C
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Nilsson, Peter
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Svenningsson, P.
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Movement Disorde ...
- By the university
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Royal Institute of Technology
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Karolinska Institutet