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Inactivation of med...
Inactivation of mediator complex protein 22 in podocytes results in intracellular vacuole formation, podocyte loss and premature death
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- Rodriguez, Patricia Q. (author)
- Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Div Pathol,Integrated Cardio Metab Ctr, Stockholm, Sweden.
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- Jess, David Unnersjö (author)
- KTH,Biofysik,Science for Life Laboratory, SciLifeLab
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- Zambrano, Sonia S. (author)
- Karolinska Institutet
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- Guo, Jing (author)
- Karolinska Inst, Dept Med Biochem & Biophys, Stockholm, Sweden.;Duke NUS Med Sch, Cardiovasc & Metab Disorders Program, Singapore, Singapore.
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- Moller-Hackbarth, Katja (author)
- Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Div Pathol,Integrated Cardio Metab Ctr, Stockholm, Sweden.
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- Blom, Hans, 1968- (author)
- KTH,Science for Life Laboratory, SciLifeLab,Biofysik
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- Jahnukainen, Timo (author)
- Univ Helsinki, Helsinki Univ Hosp, New Childrens Hosp, Dept Pediat Nephrol & Transplantat, Helsinki, Finland.
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- Ebarasi, Lwaki (author)
- Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Div Pathol,Integrated Cardio Metab Ctr, Stockholm, Sweden.
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- Patrakka, Jaakko (author)
- Karolinska Institutet
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Karolinska Univ Hosp Huddinge, Karolinska Inst, Dept Lab Med, Div Pathol,Integrated Cardio Metab Ctr, Stockholm, Sweden Biofysik (creator_code:org_t)
- 2020-11-18
- 2020
- English.
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In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 10:1
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https://doi.org/10.1...
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https://www.nature.c...
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Abstract
Subject headings
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- Podocytes are critical for the maintenance of kidney ultrafiltration barrier and play a key role in the progression of glomerular diseases. Although mediator complex proteins have been shown to be important for many physiological and pathological processes, their role in kidney tissue has not been studied. In this study, we identified a mediator complex protein 22 (Med22) as a renal podocyte cell-enriched molecule. Podocyte-specific Med22 knockout mouse showed that Med22 was not needed for normal podocyte maturation. However, it was critical for the maintenance of podocyte health as the mice developed progressive glomerular disease and died due to renal failure. Detailed morphological analyses showed that Med22-deficiency in podocytes resulted in intracellular vacuole formation followed by podocyte loss. Moreover, Med22-deficiency in younger mice promoted the progression of glomerular disease, suggesting Med22-mediated processes may have a role in the development of glomerulopathies. This study shows for the first time that mediator complex has a critical role in kidney physiology.
Subject headings
- NATURVETENSKAP -- Biologi -- Biofysik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biophysics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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