SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:kth-291350"
 

Search: onr:"swepub:oai:DiVA.org:kth-291350" > Clinicopathological...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Montero, Angeles M. (author)

Clinicopathological significance of the expression of PD-L1 in Non-Small Cell Lung Cancer

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier BV,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-291350
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291350URI
  • https://doi.org/10.1016/j.anndiagpath.2021.151701DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146275749URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • QC 20210310
  • Introduction: PD1/PD-L1 pathway targeting therapies are nowadays an established treatment option for patients with NSCLC. We assessed whether PD-L1 expression in NSCLC tumor cells was associated with specific clinical features or overall survival using four different clones. Methods and results: A retrospective study included formalin-fixed paraffin embedded (FFPE) surgical tumors from 482 patients. PD-L1 status was assessed with immunohistochemistry in tumor cells on tissue microarrays using clones 28-8, 22C3, SP263 and SP142. Associations with OS were assessed by Kaplan-Meier and multivariate Cox's regression analysis. Patients' median age: 68 years (39–86); histology: adenocarcinoma (AdCa) 61%, squamous-cell carcinoma (SqCC) 33%, and large cell carcinoma (LCC) 6%; p-stage: IA (46%), IB (30%), IIA (10%), IIB (11,4%), IIIA (1,2%), IIIB – IV (0,4%). PD-L1 positivity (≥1%) in NSCLC for clones 28-8, 22C3, SP263, SP142 was 41.5%, 34.2%, 42.7%, 10.4%, respectively (Pearson Chi-square p < 0.0001). PD-L1 expression was correlated with histology, tumor size and grading. Statistically significant association between PD-L1 expression and OS in NSCLC and Non-AdCa was observed with clone SP142 (log-rank p = 0.045 and p = 0.05, respectively). Statistically significant association between PD-L1 expression and OS in LCC was observed with clones 22C3 (log-rank p = 0.009) and SP263 (log-rank p = 0.050). Conclusions: Overexpression of the PD-L1 clone SP142 was associated with poor overall survival in NSCLC and Non-AdCa. Clones 22C3 and SP263 were associated with poor prognosis in LCC. PD-L1 status might serve as a prognostic marker in NSCLC.

Subject headings and genre

  • Lung cancer and immunotherapy
  • Predictive biomarkers in no
  • n-small cell lung cancer
  • PD-L1 status in tumor cells

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ozan, Aricak (author)
  • Kis, Lorand (author)
  • Yoshikawa, Akira (author)
  • De Petris, LuigiKarolinska Institutet (author)
  • Grundberg, OscarKarolinska Institutet (author)
  • Pham, Hoa H. N. (author)
  • Roden, Anja C (author)
  • Fukuoka, Junya (author)
  • Attanoos, Richard (author)
  • Guijarro, Ricardo (author)
  • Alarcón, Feliz (author)
  • Lindström, Kati,1977-KTH,Historiska studier av teknik, vetenskap och miljö(Swepub:kth)u171b46t (author)
  • Ortiz-Villalón, CristianKarolinska Institutet (author)
  • Karolinska InstitutetHistoriska studier av teknik, vetenskap och miljö (creator_code:org_t)

Related titles

  • In:Annals of Diagnostic Pathology: Elsevier BV51, s. 151701-1092-91341532-8198

Internet link

Find in a library

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view