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Electroosmosis Base...
Electroosmosis Based Novel Treatment Approach for Cerebral Edema
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- Wang, Teng (författare)
- KTH,Neuronik
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- Kleiven, Svein, 1966- (författare)
- KTH,Neuronik
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- Li, Xiaogai (författare)
- KTH,Neuronik
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(creator_code:org_t)
- Institute of Electrical and Electronics Engineers (IEEE), 2021
- 2021
- Engelska.
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Ingår i: IEEE Transactions on Biomedical Engineering. - : Institute of Electrical and Electronics Engineers (IEEE). - 0018-9294 .- 1558-2531. ; 68:9, s. 2645-2653
- Relaterad länk:
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https://doi.org/10.1...
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https://kth.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Objective: Cerebral edema characterized as an abnormal accumulation of interstitial fluid has not been treated effectively. We propose a novel edema treatment approach to drive edematous fluid out of the brain by direct current utilizing brain tissue’s electroosmotic property. Methods: A finite element (FE) head model is developed and employed to assess the feasibility of the approach. First, the capacity of the model for electric field prediction is validated against human experiments. Second, two electrode configurations (S and D-montage) are designed to evaluate the distribution of the electric field, electroosmotic flow (EOF), current density, and temperature across the brain under an applied direct current. Results: The S-montage is shown to induce an average EOF velocity of 7e-4 mm/s underneath the anode by a voltage of 15 V, and the D-montage induces a velocity of 9e-4 mm/s by a voltage of 5 V. Meanwhile, the brain temperature in both configurations is below 38 °C, which is within the safety range. Further, the magnitude of EOF is proportional to the electric field, and the EOF direction follows the current flow from anode to cathode. The EOF velocity in the white matter is significantly higher than that in the gray matter under the anode where the fluid is to be drawn out. Conclusion: The proposed electroosmosis based approach allows alleviating brain edema within the critical time window by direct current. Significance: The approach may be further developed as a new treatment solely or as a complement to existing conventional treatments of edema.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Cerebral edema
- Electroosmotic flow
- Electric field
- FE head model
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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