SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:kth-291752"
 

Search: onr:"swepub:oai:DiVA.org:kth-291752" > Integrated Single C...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Carlberg, KonstantinKTH,Genteknologi,Science for Life Laboratory, SciLifeLab (author)

Integrated Single Cell and Spatial Transcriptomics Reveal Autoreactive Differentiated B Cells in Joints of Early Rheumatoid Arthritis

  • BookEnglish

Publisher, publication year, extent ...

  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:kth-291752
  • https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-291752URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:vet swepub-contenttype
  • Subject category:ovr swepub-publicationtype

Notes

  • QC 20210322
  • Rheumatoid Arthritis (RA) is a prevalent autoimmune disease characterized by inflammation of peripheral joints. Patients can be subdivided by the presence or absence of Rheumatoid Factor and anti-citrullinated protein antibodies (ACPA) in their circulation. Inflammation of the joint tissue is associated with infiltration of leukocytes from the blood, which can result in generation of lymphoid structures composed of B and T cells. Previous studies have shown that both memory B cells and antibody-secreting plasma cells populate the rheumatic joint tissue when captured from established and often long-standing disease. However, it has remained unclear, whether these cells are autoreactive and whether the associated lymphoid structures are present at the site of inflammation already at the time of diagnosis. Here, we used an integrated single cell and spatial transcriptomic approach to study B and plasma cells in synovial tissue of ACPA- and ACPA+ RA patients at this early time point. We found evidence for T cell help to B cells and presence of memory B and plasma cell pools in ACPA- as well as in ACPA+ RA. Our results demonstrated common supportive microenvironments in both patient subgroups, clonal relationships between the memory B and plasma cell pools and autoreactivity within the plasma cell compartment. These findings challenge our understanding of the dynamics of local adaptive immune responses in the RA joint of ACPA- and ACPA+ patients at the time of diagnosis, with direct implications for B and T cell targeting therapies for both patient subgroups. 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hardt, Uta (author)
  • af Klint, Erik (author)
  • Sahlström, Peter (author)
  • Larsson, LudvigKTH,Genteknologi,Science for Life Laboratory, SciLifeLab(Swepub:kth)u13lw4hm (author)
  • van Vollenhoven, Annika (author)
  • Hernandez Machado, Susana (author)
  • Israelsson, Lena (author)
  • Amara, Khaled (author)
  • Chemin, Karine (author)
  • Korotkova, Marina (author)
  • Karlsson Hedestam, Gunilla (author)
  • Catrina, Anca (author)
  • Teichmann, Sarah (author)
  • Ståhl, Patrik,Dr.KTH,Science for Life Laboratory, SciLifeLab,Genteknologi(Swepub:kth)u1rstx38 (author)
  • Malmström, Vivianne (author)
  • KTHGenteknologi (creator_code:org_t)

Internet link

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view