A conversational robotic lab assistant for automated microfluidic 3d microtissue production

• The future of life science is linked to automation and microfluidics. Here we present a robotic lab assistant, a general automation platform for droplet microfluidics including a conversational mobile interface. We demonstrate the automated production of human cancer microtissues in droplets at a throughput of 85000 spheroids per microfluidic circuit per hour. The capability of automated spheroid generation is directly applicable to precision medicine and drug screening. Multiple cell lines were successfully tested, including cancer cell lines, co-cultures, and primary cells. The 3D-microtissues/spheroids were automatically assembled-incubated-retrieved with high viability for further drug screening analysis - the platform interfaces with standard labware.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology (hsv//eng)

TEKNIK OCH TEKNOLOGIER  -- Industriell bioteknik -- Läkemedelsbioteknik (hsv//swe)

ENGINEERING AND TECHNOLOGY  -- Industrial Biotechnology -- Pharmaceutical Biotechnology (hsv//eng)

NATURVETENSKAP  -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)

NATURAL SCIENCES  -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)

Keyword

3D-microtissues

Automation of droplet microfluidics

Drug screening

Robotic lab assistant

Cell culture

Diagnosis

Diseases

Drops

Robotics

Throughput

Automated productions

Cancer cell lines

Droplet microfluidics

Microfluidic circuit

Mobile interface

Multiple cells

Platform interface

Microfluidics

Publication and Content Type

ref (subject category)

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