Scalable Dendritic Hydrogels Targeting Drug-Resistant Skin Pathogens and the Immunomodulation Activity in Keratinocytes

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Fan, YanmiaoKTH,Ytbehandlingsteknik (author)

Scalable Dendritic Hydrogels Targeting Drug-Resistant Skin Pathogens and the Immunomodulation Activity in Keratinocytes

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LIBRIS-ID:oai:DiVA.org:kth-295582
https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-295582URI

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Language:English
Summary in:English

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Subject category:ovr swepub-publicationtype

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QC 20210531
Microbial infections caused by antibiotic-resistant bacteria are a major threat to humans, associated with a high mortality and for the society increased economic burden. To address this, a series of cationic hydrogels based on amino-functional hyperbranched dendritic−linear−dendritic copolymers (HBDLDs) were formed easily within 1 min through interactions between the amino-terminated HBDLDs and di(N-hydroxysuccinimide ester) functionalized polyethylene glycol (PEG). The hydrogels exhibited excellent inherent antimicrobial activity towards a wide range of Gram-positive and Gram-negative clinical bacteria including drug-resistant strains, isolated from wounds. In vitro cell infection assays showed that the hydrogels were able to significantly reduce cell infections caused by different strains, with the highest killing efficacy of 96% towards S. aureus. The hydrogels also inhibited the initiation of E. coli biofilm formation. Remarkably, the hydrogels induced the expression of the antimicrobial peptides, RNase 7 and psoriasin, in keratinocytes (HaCaT) which suggests that the hydrogels are likely able to promote host-mediated bacterial killing. The expression of pro-inflammatory cytokine IL-1β, reactive nitrogen species (NO) and mitochondrial reactive oxygen species (ROS) in S. aureus-infected HaCaT cells were reduced after the treatment with the hydrogels. The hydrogels degraded within 24 h, showing great promise for treating skin infections and reducing inflammation.

Subject headings and genre

cationic dendritic hydrogels
antimicrobial
drug-resistant bacteria
wound dressing

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Mohanty, Soumitra (author)
Zhang, YuningKTH,Fiber- och polymerteknologi(Swepub:kth)u1bh78yi (author)
Lüchow, MadsKTH,Fiber- och polymerteknologi(Swepub:kth)u1x2ksfd (author)
Qin, LiguoKTH,Fiber- och polymerteknologi(Swepub:kth)u1qdnq3n (author)
Fortuin, LisaKTH,Fiber- och polymerteknologi(Swepub:kth)u1l5i7al (author)
Brauner, Annelie (author)
Malkoch, Michael,1974-KTH,Ytbehandlingsteknik(Swepub:kth)u18z6ljf (author)
KTHYtbehandlingsteknik (creator_code:org_t)

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https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-295582

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By the author/editor: Fan, Yanmiao; Mohanty, Soumitr ...; Zhang, Yuning; Lüchow, Mads; Qin, Liguo; Fortuin, Lisa; show more...; Brauner, Annelie; Malkoch, Michael ...; show less...

By the university: Royal Institute of Technology

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