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Stress-induced transcriptional memory accelerates promoter-proximal pause release and decelerates termination over mitotic divisions
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- Vihervaara, Anniina (author)
- KTH,Genteknologi,Science for Life Laboratory, SciLifeLab,Abo Akad Univ, Fac Sci & Engn, Cell Biol, Turku 20520, Finland.;Univ Turku, Turku Biosci Ctr, Turku 20520, Finland.;Abo Akad Univ, Turku 20520, Finland.;Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA.
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- Mahat, Dig Bijay (author)
- Cornell Univ, Dept Mol Biol & Genet, Ithaca, NY 14853 USA.;MIT, 77 Massachusetts Ave, Cambridge, MA 02139 USA.
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- Himanen, Samu, V (author)
- Abo Akad Univ, Fac Sci & Engn, Cell Biol, Turku 20520, Finland.;Univ Turku, Turku Biosci Ctr, Turku 20520, Finland.;Abo Akad Univ, Turku 20520, Finland.
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- (creator_code:org_t)
- Elsevier BV, 2021
- 2021
- English.
- In: Molecular Cell. - : Elsevier BV. - 1097-2765 .- 1097-4164. ; 81:8, s. 1715-
- Journal article (peer-reviewed)
Abstract
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- Heat shock instantly reprograms transcription. Whether gene and enhancer transcription fully recover from stress and whether stress establishes a memory by provoking transcription regulation that persists through mitosis remained unknown. Here, we measured nascent transcription and chromatin accessibility in unconditioned cells and in the daughters of stress-exposed cells. Tracking transcription genome-wide at nucleotide-resolution revealed that cells precisely restored RNA polymerase II (Pol II) distribution at gene bodies and enhancers upon recovery from stress. However, a single heat exposure in embryonic fibroblasts primed a faster gene induction in their daughter cells by increasing promoter-proximal Pol II pausing and by accelerating the pause release. In K562 erythroleukemia cells, repeated stress refined basal and heat-induced transcription over mitotic division and decelerated termination-coupled pre-mRNA processing. The slower termination retained transcripts on the chromatin and reduced recycling of Pol II. These results demonstrate that heat-induced transcriptional memory acts through promoter-proximal pause release and pre-mRNA processing at transcription termination.
Subject headings
- NATURVETENSKAP -- Biologi -- Cellbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Cell Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
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